This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Pyrrole nucleus is one of the most important heterocycles abundantly found in bioactive natural molecules, forming the
characteristic subunit of heme, chlorophyll vitamin B12 as well as in melanin pigments. 1,2,5-Trisubstituted pyrroles display
interesting biological properties, such as anti-inflammatory, antipsychotic, spasmolytic and radioprotective. Two clinical examples
of pyrroles displaying this pattern of substitution are amtolmetin and tolmetin (non-steroidal anti-inflammatory agents). Generally,
pharmaceuticals containing pyrroles are of high value as biological agents such as sunitinib (anti-tumor), ketorolac (analgesic) and
the highly successful cholesterol-lowering drug atorvastatin calcium (Lipitor), which is notable as the first drug to earn in excess
of $1 billion of sales in its first year. The electronic properties of pyrrole are important in the context of conducting polymers,
where poly-pyrroles have found many useful applications. Herein, we report a new and facile method for the synthesis of 2,5-di
and 2,3,5-trisubstituted pyrrole using intramolecular reductive cyclization of the easily accessible nitrodienes as starting material
catalyzed by palladium complex and with carbon monoxide as a reductant.
Mohamed A El-Atawy has completed his PhD in organic chemistry, department of chemistry, University of Milan, Italy. Currently, he is working as an Assistant Professor in Alexandria University, Egypt.