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Quantification Of Synchronous Contraction Of Left Ventricle In Normal Subjects Using ECG-gated- SPECT Images | 16664
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Quantification of synchronous contraction of left ventricle in normal subjects using ECG-gated- SPECT images

4th International Conference on Clinical & Experimental Cardiology

Hisatoshi Maeda

Accepted Abstracts: J Clin Exp Cardiolog

DOI: 10.4172/2155-9880.S1.021

Regional contraction work (RCW) of left ventricle (LV) was evaluated from cardiac perfusion images of ECG-gated single photon emission computed tomography (ECG-SPECT). The mechanical work was computed as a product of force and displaced distance. Force was determined from Laplace?s law under a rectangle pressure. Deformation of wireframe representing LV was calculated from equations of continuity for two-dimensional fluids. Experiments were performed with homemade life-sized cardiac models. Total contraction work (TCW) and stroke work (SW) were 524.0 ?} 166.1 mJ/beat and 709.8 ?} 169.5 mJ/beat, respectively, in normal subjects (n = 23). Moderate correlation was seen between TC WandSW(y=−43.4+0.779 x, r=0.815). The regional contraction amplitude (RCA), synchronous contraction index and RCW were 35.4 ?} 3.5%, 95.4 ?} 3.1% and 5.58 ?} 0.97 mJ cm−2/beat in normal subjects, whereas those in patients with decreased ejection raction (EF) 30% (n = 6) were 19.6 ?} 7.7%, 64.4 ?} 32.2% and 2.58 ?} 0.82 mJ cm−2/beat (p < 0.0001, Student?s t-test). There was a poor correlation between RCW and RCA (y = 1.648 ?} 0.116 x, r = 0.501) in normal subjects, suggesting that it might not be suitable to use RCA as an alternative to evaluate RCW
Hisatoshi Maeda is a Professor of Emeritus at Nagoya University. He got MS in engineering from Tokyo University and MD from Kyoto University, and has finished Ph.D. at California Institute of Technology