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Quantitative Tracking Of Individual TCR Repertoires | 5270
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Quantitative tracking of individual TCR repertoires

International Conference & Exhibition on Cell Science & Stem Cell Research

Dmitriy M Chudakov

Accepted Abstracts: J Cell Sci Ther

DOI: 10.4172/2157-7013.S1.16

Abstract
Th e individual repertoire of T Cell Receptors (TCRs) is a mirror of functioning of an immune system that keeps detailed information concerning infectious and autoimmune conditions. We have developed approach that enables unbiased quantitative analysis of the human TCR V beta repertoire by massive sequencing. Using this approach, we have performed the fi rst detailed tracking of the fate of human T cell clones aft er high dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT). We show that multiple T cell clones do survive the transplantation procedure, some of them being essentially suppressed, but some of them expanding and fi ghting infections early aft er HSCT. We believe that wide application of the proposed approach will lead to optimization of HSCT protocols, progress in understanding infection and autoimmunity, and development of individual sequence-based diagnostics of immune status
Biography
DM Chudakov has completed his PhD at the age of 25 years from Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS (Moscow, Russia). Starting form 2008, he is a head of the laboratory of Fluorescent instruments for immunology and neurobiology in the same institute. He has published more than 50 papers in reputed journals
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