alexa Quasi Emulsion Spherical Crystallization Technique Based Environmentally Responsive Tulsion® (pH Dependent) Microspheres For Colon Specific Delivery | 69257
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
Open Access

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8th World Congress on Pharmacology and Toxicology
July 24-25, 2017 Melbourne, Australia

Ashish Jain
Dr. Hari Singh Gour University, India
Posters & Accepted Abstracts: Clin Exp Pharmacol
DOI: 10.4172/2161-1459-C1-020
Abstract
Statement of the Problem: pH-dependent sustained-release Tulsion® microspheres bearing clarithromycin were developed for colon specific release so that a broad spectrum of diseases can be treated well. Methodology & Theoretical Orientation: Clarithromycin bearing Tulsion® microspheres were prepared using quasiemulsion solvent diffusion method (spherical crystallization technique) with thermocoat L 30 D-55. Both, clarithromycin and thermocoat L 30 D-55 were evaluated for in vitro toxicity assay against human red blood cells. Ratiometric optimization of different solvents using phase diagrams was performed on amount of good solvent, bridging liquid, dispersing liquid and poor solvent. Findings: Both, clarithromycin and thermocoat L 30 D-55 were found to be non-hemolytic during in vitro toxicity assay against human red blood cells. The developed microspheres were evaluated for the recovery (67.27±3.3%), average particle size (52.0±0.46 μm) and encapsulation efficiency (61.0±3.1%). Scanning electron microscopy and transmission electron microscopy revealed that the microspheres were smooth in surface and spherical in shape, respectively. The drug release study was conducted at different pH of GIT and it gave a pH dependent release for clarithromycin. Conclusion & Significance: The manuscript reported the debut work on thermocoat L 30 D-55 based novel drug delivery system, the polymer is safe to be used, quasi emulsion spherical crystallization technique is a good technique to prepare microspheres, the prepared microspheres provides sustain release profile as well as targeting to colon.
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