alexa Quiescent Pluripotent Stem Cells Capable Of Expressing SOX2, OCT4, KLF4 And C-Myc Reside Within Peripheral Nerves In Adult Mammals And Can Differentiate Into Cells Of All 3 Germ Layers
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th International Conference on Tissue Science and Regenerative Medicine
September 11- 12, 2017 Singapore

Michael H Heggeness and S Yang
University of Kansas School of Medicine, USA
ScientificTracks Abstracts: J Tissue Sci Eng
DOI: 10.4172/2157-7552-C1-036
Abstract
Preliminary evidence from our laboratory has documented a large population of quiescent stem cells within peripheral nerves. In response to nerve injury, or stimulation with the cytokine BMP2, these cells proliferate and generate populations of pluripotent stem cells, expressing Sox2, Klf4, Oct4 and c-Myc (verified by double stain immunohistochemistry and by real time PCR). These 4 markers are the transcription factors that confer embryonic pluripotency (Cell 126: 663, 2006). We call them Nerve Derived Pluripotent Stem cells, or NEDAPS cells. The cells are readily induced to form tissues from all 3 germ layers. We hypothesize that these cells are central to a previously unknown universal pathway for tissue repair. Nerves are nearly ubiquitous in the body, from the cornea of the eye to every hair follicle. Thus, we believe that nerve injury, and the consequent proliferation of these stem cells, is occurring following essentially any injury. We propose that this is a previously unknown universal pathway for healing. We will show data documenting the induction and successful culture pluripotent cells from three mammalian species, and demonstrate their directed differentiation into osteoblasts, endothelial cells, primitive neural cells, definitive endoderm and fibroblasts as demonstrated by morphology, immunohistochemical staining and RT-PCR. Recent progress has been stimulated by the discovery that induced pluripotent stem cells (iPCs), can be created from fully differentiated cells using retrovirus vectors (Cell 126: 663,2006). Such iPCs are widely studied as possible sources of cells for the treatment of human disease. This work has almost entirely been focused on a search for cures and treatments for specific diseases, and has been hampered by issues of malignant transformation of iPCs, and by immune rejection of “non-self ” cells. We are aware that previous claims to successful identification of cells with universal differentiation from non-gonadal adult tissue have resulted in some well publicized scandals, involving fabricated data. These scandals have understandably created a skeptical audience for us. Such pluripotent stem cells are thought not to exist in adult animals (SciON 311: 814 2006), and until our recent discovery, we believed the same. Confidence in our admittedly unprecedented ideas is provided by information from other species. It is known that a salamander can re-grow an entire arm after amputation, but that ablation of the nerve stump will block the regeneration. Similarly, a starfish will regenerate an entire arm as well, but similarly, will not do so if the nerve supply is ablated (Kumar and Brokes Trend. Neurosci 2012 p691). We propose that this new knowledge will also explain the puzzling and vexing clinical problem of impaired wound healing experienced by severely diabetic patients and victims of leprosy. We suggest that the associated clinical neuropathies explain this. The other implication of this discovery is that we may now have a new opportunity for individual specific “self-to-self ” stem cell treatments, based on patient specific peripheral nerve harvest.
Biography

Michael H Heggeness has completed his PhD at UC San Diego in Membrane Biology and a Post-doctorate at Rockefeller University in Virology. He has received his MD from the University of Miami. After his Residency in Orthopedic Surgery, he has completed a Fellowship in Spine Surgery at the University of Toronto. He has then joined the Faculty at Baylor College of Medicine where he became Chairman of Orthopedic Surgery in 2004. He then moved to take the chair at University of Kansas in Wichita in 2013. He has 84 publications and 4 issued patents to his credit. His interest has centered on intraosseous nerves and nerve derived stem cells.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords