Journal of Vaccines & Vaccination

Rapid immunization effects of a new type of 60 μg hepatitis B vaccine compared with traditional 20 μg hepatitis B vaccines in adults

10^th Euro Global Summit and Expo on Vaccines & Vaccination

June 16-18, 2016 Rome, Italy

Wei Zhang

Beijing Center for Disease Control and Prevention, China

Posters & Accepted Abstracts: J Vaccines Vaccin

Abstract:

Background: The widely recommended standard schedule of hepatitis B vaccine for adults is months 0, 1 and 6 which needs 6 months to complete. Rapid completion one vaccination schedule is important for adults because of the less compliant with follow up doses. A new type of 60 μg hepatitis B vaccine, made by Shenzhen Kangtai Biological Products Co., LTD., is originally recommended for low or non responders. Whether the 60 μg hepatitis B vaccine could be used in primary immune population and what�??s the immunogenicity and safety compared to other hepatitis B vaccines need to be tested. Methods: This is a two center randomized controlled study. A total of 1169 healthy adults aged between 25 and 55 years who tested negative for HBsAg, anti-HBs and anti-HBc were eligible for the study and were enrolled from relatively fixed and stable sites such as village, school and large enterprises et al in Xuanhua County in Hebei province and Huaibei County in Anhui province. They were randomized to group A (20 μg Engerix-B® with 0, 1, 6 month intervals), group B (20 μg Kangtai hepatitis B vaccine with 0, 1, 6 month intervals), group C (60 μg Kangtai hepatitis B vaccine with 0, 2 month intervals) and group D (20 μg Huabei hepatitis B vaccine made by recombinant DNA techniques in CHO cell). Every study object�??s bloods were collected in second month after the final injection to test the anti-HBs levels in group A, B and D. Bloods was collected in second month after the first and second injection to test the anti-HBs levels in group C. Adverse events were collected after each dose to assess safety. Results: The seroprotection rates were 93.17%, 97.23%, 93.54% and 98.98% respectively and the geometric mean titers (GMTs) were 1033.38 mIU/ml, 600.75 mIU/ml, 265.69 mIU/ml and 1627.05 mIU/ml respectively in A, B, C, D groups. The difference of seroprotection rate among the four groups was statistically significant (�?2=17.26, P<0.05). The difference of titers of anti-HBs among the four groups was statistically significant (H=162.42, P<0.05). BMI, old age and smoking were the influence factors of anti-HBs levels. Conclusion: 60 μg of hepatitis B vaccine has a satisfactory safety and immunogenicity in adult. It could be used in rapid adult hepatitis B immunization.

Biography :

Email: zhangweipumc@163.com