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Recent Advances In Asymmetric Organocatalytic Staudinger Synthesis Of β-lactams | 62316
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Recent advances in asymmetric organocatalytic Staudinger synthesis of β-lactams

International Conference on Stereochemistry

Plato A Magriotis

University of Patras, Greece

Posters & Accepted Abstracts: Med chem

DOI: 10.4172/2161-0444.C1.022

In recent years, organocatalysts have dominated the field of asymmetric organic synthesis due to their ability to catalyze a variety of fundamentally important transformations. One example is the Staudinger synthesis of β-lactams which continue to provide unique opportunities for the design and synthesis of new derivatives with unprecedented biological profiles other than antibacterial activity. In fact, during the last two decades medicinal chemists have convincingly demonstrated that structural modifications of monocyclic β-lactams (monobactams) is an effective protocol for the discovery of new derivatives with novel pharmacological profiles. This lecture will cover recent progress that has been made in asymmetric organocatalytic Staudinger synthesis of β-lactams since the inaugural and pioneering investigations by Lectka and coworkers around the turn of the century, as well as our own efforts toward the development of a novel Gilman-Speeter process for the catalytic enantioselective synthesis of β-lactams.

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