alexa Regenerated Liver From Human Tooth Pulp Treats Swine Liver Failure Started By NAFLD
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

Global Congress on Tissue Engineering, Regenerative & Precision Medicine
December 1-2, 2016 | San Antonio, USA

Ken Yaegaki
The Nippon Dental University, Japan
Keynote: J Tissue Sci Eng
DOI: 10.4172/2157-7552.C1.029
The number of cadaveric or live-donor liver transplantation is very limited, because of fewer available organs; the liver regeneration might be a substitution of the transplantation mention above. Hence, research endeavor has been focused on developing a protocol for regenerative medicine of the liver. Not only preclinical studies but also some clinical studies were carried out with transplanting mesenchymal stem cells, i.e., CD34 positive cells from blood, bone marrow or adipose tissue into the livers accompanied with severe condition but the transplantation protocol of hepatic differentiated cells has not yet well reported. Transplantation of these cells can only decelerated the progress of hepatic failure in animal or human. It is very difficult to treat the conditions of the liver with present protocol employing stem cell or regenerative medicine. These days, it was almost concluded that regenerative medicine is valuable only for postpone getting the final stage of severe liver conditions or for prolong the waiting time for cadaveric or live-donor liver transplantation; “bridge to transplant” strategy rather than treating liver failure. We have shown that human dental pulp stem cell demonstrated a big potential for curing lethal liver diseases. Our preclinical study has described that the biliary liver cirrhosis and acute liver injury in rats were treated with transplanting the regenerated liver tissues derived from human dental pulp. One of the worse liver conditions is non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). Hence the objectives of this paper is to determine a possibility of treating severe liver failures by our transplantation protocol of the regenerated liver tissues derived from human dental pulp with using swine model of liver failure progressed from NAFLD. After four weeks of transplantation into 6 swine with the failure, the secondary liver was regenerated in the spleen as well as the regenerated liver was produced: The original liver was utilized as a scaffold. Biliary ducts were also reproduced with human tissues only 4 weeks after the transplantation but partially. Serum albumin concentration was raised from 1.5 g/dL to over 3.0 g/dL. HPT, choline esterase, collagen type-IV, ALT and others have been considerably improved.

Ken Yaegaki has completed his PhD in Medicine at Kureme University School of Medicine and Postdoctoral studies from University of British Columbia. He was trained as Oral Maxillofacial Surgeon. He has worked at UBC Dentistry as a Clinical Professor and moved to Oral Health at Nippon Dental University and he is also a Dean of PhD program. He has published more than 100 papers and 20 books. He has been serving as an Editorial Board Member of repute.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version