alexa
Reach Us +1-217-403-9671
Regularity In The Amino Acid Sequences Of Proteins | 8971
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Regularity in the amino acid sequences of proteins

3rd International Conference on Proteomics & Bioinformatics

Chanchal Das Gupta

ScientificTracks Abstracts: J Proteomics Bioinform

DOI: 10.4172/0974-276X.S1.067

Abstract
The transit of proteins from linear to tertiary states should be exactly tractable because the tertiary states have unambiguous crystalline forms. Since the amino acids interact in the water environment, the solution for the folding problem should give due consideration to the hydrophobic / hydrophilic indices of the amino acids, as mentioned in many studies. Representing amino acids by these indices, we find two different kinds of regularity in amino acid sequence of cytosolic and membrane proteins. If we take the mean hydrophobicity for every few percent of amino acids in proteins and plot them in a cumulative fashion from the N to the C termini, we get two different kind of smooth graphs for cytosolic and membrane proteins.. More than 100 cytosolic proteins and 30 membrane proteins of widely varying number of amino acids and structures could be represented in two such smooth graphs with small standard errors. What we know so far, for cytosolic proteins, is that this regularity comes from a simple working principle which can be based on our observation on the kinetics of folding of a number of proteins starting from the N-termini and extending to the C-termini through a sequential interaction with the same set of nucleotides in the peptidyl transferase center (PTC) of the ribosome.
Biography
Chanchal Das Gupta received Ph.D. (Biophysics) from Calcutta University. Post doctoral research on the role of RecA protein in recombination at Yale University, USA (1978-82). He worked as Professor, Calcutta University and IISER-Kolkata till 2012. Senior Fellow (Indian National Science Academy) at Jadavpur University, Kolkata, India.
Leave Your Message 24x7
Top