alexa Regulation And Function Of Immune Suppressive Myeloid Cells In Systemic Autoimmunity
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Trine N Jorgensen
ScientificTracks Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.017
Abstract
Systemic lupus erythematosus is an autoimmune disease characterized by elevated production of auto-reactive antibodies and systemic inflammation. Nine out of ten patients suffering from SLE are female. Sex hormones have been extensively studied for their potential effects on disease pathogenesis. It is thus known that testosterone protects while estrogens exacerbate disease development. We have recently described a population of Gr1+CD11b+ cells that are upregulated in male lupus- prone (NZB x NZW)F1 mice. These cells are driven by testosterone in a dose-dependent manner, as revealed by castration and hormonal reconstitution studies. Interestingly, although Gr1+ cells from both male and female prepubescent (NZB x NZW)F1 mice are immunosuppressive, the suppressive capacity is driven by different mechanisms and only male-derived cells remain immunosuppressive after puberty. In support hereof, adult 9 week old male mice depleted of Gr1-expressing cells develop increased levels of antibodies to both thymus-dependent antigens (NP-CGG) and nuclear auto-antigens, while a similar depletion strategy in age-matched females had no effect on either NP-specific antibody production or the spontaneous appearance of anti-nuclear autoantibodies. Further studies revealed that Gr1+ cell depletion in adult (NZB x NZW)F1 male mice resulted in increased levels of TFH and GC B cells after immunization. We conclude that a population of testosterone- driven Gr1+ cells present in (NZB x NZW)F1 lupus-prone male mice exert a hitherto unappreciated role in controlling activation of the adaptive immune system and the development of lupus-like disease. Manipulation of these cells represents an interesting new target for immunotherapy in autoimmune disorders with a female predominance.
Biography
Trine N Jorgensen obtained her PhD from The University of Southern Denmark in 2002. She completed her Postdoctoral studies at the University of Colorado, Denver Health Sciences Center studying the importance of sex hormones and type I interferon signaling in lupus. In 2007, she joined the faculty at the Lerner Research Institute at the Cleveland Clinic as an Assistant Professor. She has published more than 25 papers and reviews in reputed journals and serves as an ad hoc reviewer for numerous scientific journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords