Regulation Of Angiogenesis By Endogenous Metabolite | 3559
Journal of Molecular Biomarkers & Diagnosis
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Choroidal neovascularisation is the primary cause of blindness in a variety of common retinal diseases including retinopathy
of prematurity, age related macular degeneration, proliferative diabetic retinopathy, among other vascular diseases.
Angioinhibitory therapies are starting to give hopeful results in these ocular diseases. In this study the angioinhibitory activity of
endogenous metabolite derived from extra cellular matrix was analyzed in-vitro and in-vivo. Mouse choroidal endothelial cells
treated with different doses of endogenous metabolite and performed in-vitro proliferation, migration and tube formation assays.
Matrix metalloproteinase-2 (MMP-2) activation and MMP-2/endogenous metabolite complex formation were studied using
different methods. In-vitro angioinhibitory effects of endogenous metabolite were studies in different mice models. Endogenous
metabolite demonstrated anti-proliferative activity and inhibits mouse choroidal endothelial cells migration, tube formation
in-vitro. Endogenous metabolite binds pro-MMP-2 and inhibits its activation mediated by both membrane-type-1 MMP
and 4-amino-phenyl mercuric acetate in-vitro. Endogenous metabolite also confirmed that significant inhibition of integrin
dependent and independent in-vivo and in-vivo angiogenesis.
Smita C. Pawar Assistant Professor (2004 - till date), former Head, Department of Genetics, Osmania University, Hyderabad, India, has more
than eight years of experience in teaching, research and University administration. She is the recipient of CSIR/NET/UGC-JRF (2003) fellowship
from Government of India. She worked in a reputed national research ICMR Institute ?National Institute of Nutrition? as Junior Research Fellow
(2003-2004). She was awarded the DST-ITS grant to present a research article in an international conference ?BDC 2010?- at Sydney, Australia.
She has been awarded the BOYSCAST FELLOWSHIP by DST, Government of India for the year 2011-2012. She is currently Visiting Scientist at
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA and Cell Signaling, Retinal and
Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA. She is research supervisor and
has two ongoing major research grants funded by UGC and DBT.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals