alexa Regulation Of Metastasis By Endogenous Metabolite
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Tissue Science & Regenerative Medicine
September 24-26, 2014 Valencia Convention Centre, Spain

Sudhakar Yakkanti
ScientificTracks Abstracts: J Tissue Sci Eng
DOI: 10.4172/2157-7552.S1.014
Abstract
M etastasis is frequently deadlier than the original tumor-ultimately, reducing the risk or occurrence of metastasis could effectively cure or at least manage human cancer. My laboratory has carried out research that could significantly contribute to the control of malignant progression, involving the use of endogenous metabolite that is released from the extracellular matrix, which is both an endogenous angiogenesis inhibitor and anti-metastatic molecule. The signaling mechanism(s) underlying the influence of these metabolites on regulation of tumor angiogenesis is known, where as regulation of tumor metastasis are not yet known. We identified that one of the endogenous metabolite binds to different cell surface integrins, inhibits different cellular signaling in a manner distinct from that of other metabolites studied to date. Treatment of endothelial cells with this metabolite specifically inhibiting κ -elastin mediated phosphorylation of FAK, Akt, mTOR and PI-3K signaling. In additiondifferent in-vitro and in-vivo studies, we found that this metabolite possibly binding to Laminin D-III and D-IV domains and inhibits Laminin degradation by the matrix metalloprotease-14 (MMP-14), and thereby reduces the generation of different sized Laminin peptides that can bind to the EGF receptor and promote cancer metastasis, in addition to its integrin(s) mediated signaling. Our findings suggest that this metabolite interacting with different cell surface integrins and cross talking with othermolecules and inhibiting tumor angiogenesis and tumor metastasis both in-vitro and in-vivo
Biography
Sudhakar Yakkanti, Former Associate Director at Center for Cancer & Metabolism, Bioscience Division, California, San Fransisco. He did his postdoctoral training at Harvard Medical, Boston USA. He received Indian President?s fellowships, YCS, Michael A. O?Connor Young Investigator Awards from FAMRI and Mayo Clinic. He has more than 40 research articles including Science, JCI, Blood, PNAS etc. His research focuses on cell signaling and tumor metastasis, which is supported by NIH and foundation grants. He was served as grant reviewer for DT study section. He is serving as an Editor-in-Chief and also honored as keynote speaker and session chair for many conferences.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords