Journal of Nutrition & Food Sciences
Open Access

Regulation of NF-κB by dietary curcumin in ovarian cancer

9^th International Congress on Nutrition & Health

February 20-21, 2017 Berlin, Germany

Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Hakki Tastan, Ibrahim Hanifi Ozercan, Osman Guler, Nermin Kahraman, Omer Kucuk and Bulent Ozpolat

Firat University, Turkey
Gazi University, Turkey
Veterinary Control Research and Institute, Turkey
University of Texas, USA
Emory University, USA

Posters & Accepted Abstracts: J Nutr Food Sci

Abstract :

Ovarian cancer is the most lethal gynecological cancer with 30% 5-year survival rate. High mortality rate is attributed to lack of early diagnostic tests and effective curative therapeutic regimens. Curcumin, a polyphenolic compound found in turmeric products, has been shown to be associated with reduced cancer incidence in populations consume high turmeric in their diet. Nuclear factor kappa B (NF-�?ºB) signaling is currently recognized as a useful strategy in cancer treatment and prevention. However, a direct link between curcumin intake and regulation of NF-�?ºB in ovarian cancer is yet to be established. Here, we investigated the effect of daily dietary curcumin intake on the NF-�?ºB pathway of spontaneous ovarian cancer in a hen model, the only non-human animal that spontaneously develops cancer with a high prevalence. At the end of 12 months, the analysis of the tumors revealed that NF- �?ºB signaling were significantly inhibited by curcumin intake in a dose-dependent manner (P<0.05). In conclusion, the results of our study demonstrated for the first time that daily curcumin intake leads to a significant and dose-dependent inhibition of NF-�?ºB signaling in the development of spontaneous ovarian cancer indicating a tremendous role of curcumin as a chemo preventive strategy against ovarian cancer.

Biography :

Email: nsahinkm@yahoo.com