alexa Regulatory Role Of Lycopene On Liver Enzymes In Diethylnitrosamine Administrated Rats
ISSN: 2157-7579

Journal of Veterinary Science & Technology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

7th International Veterinary Congress
September 04-05, 2017 | Paris, France

Emre Kaya, Seval Yilmaz and Selda Telo
Firat University, Turkey
Posters & Accepted Abstracts: J Vet Sci Technol
DOI: 10.4172/2157-7579-C1-025
Abstract
Statement of the Problem: Diethylnitrosamine (DEN) is a potent genotoxic nitroso carcinogen that induces hepatocellular carcinomas in rat liver. Methodology & Theoretical Orientation: In this study, adult male Wistar-Albino rats were used. Rats were divided into five groups as follows; control group, lycopene group (lycopene was administered), DEN group (DEN was administered), lycopene+DEN group (lycopene administration was started 10 days before the DEN administration) and DEN+lycopene group (Lycopene administration was started together with the DEN administration). DEN was administered to rats at 200 mg/ kg/bw, a single dose i.p. for 90 days. Lycopene was administered to rats every other day at 10 mg/kg/bw, gavage for 10 days. Plasma aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK) activities and cholesterol levels were determined. Findings: It wasn’t found statistically significant difference in plasma AST, ALT, ALP, LDH, CK activities and cholesterol level in the lycopene group when compared with the control group. Plasma AST, ALT, ALP, LDH, CK activities and cholesterol levels were detected to significant increases in the DEN group when compared with the control group (p<0.001). Plasma AST, ALT, LDH activities and cholesterol level were detected to decrease in the lycopene+DEN and DEN+lycopene groups when compared with the DEN group (p<0.05). However, plasma ALP and CK activities were not changed in the lycopene+DEN and DEN+lycopene groups when compared with the DEN group. Conclusion & Significance: It was observed that DEN causes a change to in some liver specific enzymes in plasma of DEN administered rats. These results indicate that lycopene might have a protective effect against DEN induced hepatotoxicity by regulating these enzymes.
Biography

Emre Kaya is a PhD in Department of Biochemistry, Faculty of Veterinary Medicine, Firat University, Turkey, Turkey. He is continuing his scientific studies in various subjects in the same place. His work focuses more on oxidative stress and its prevention.

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords