Attempts have been made to prepare nanocomposites based on medical grade HTV
silicone rubber and organoclay with varying amount of clay compositions.
Incorporation of the nanosilicate platelets onto the silicone rubber matrix was carried
out via melt mixing process by using a Brabender internal mixer. Tensile elastic modulus
of the nanocomposites was measured by performing tensile test on the samples.
Nanocomposites with different flexibility and crosslink density were studied as
substrate for the investigation of cell behavior including attachment, biocompatibility
and morphology of endothelial cells, and differentiation potential and extracellular
matrix remodeling of human adipose-derived stem cells. The results showed that
viability, proliferation and spreading of cells are governed by the microstructure and
elastic modulus and stiffness of samples. Furthermore, hASCs cultured on PDMS and
corresponding nanocomposites could retain differentiation potential into osteocyte with
or without soluble factors, indicating that not only inclusion of organoclay would
not prevent osteogenic differentiation, but also cause better differentiation of hASCs.
Moreover, better endothelial cell spreading and proliferation associated with ECM
remodeling in hASCs was observed for the nanocomposite samples.
Nanocomposite, Micro-structure, Biocompatibility, Differentiation, ECM
I received MSc and Ph.D degree in polymer engineering at Birmingham University of England.
Academic activity was started in 1981 at polymer engineering department of Amirkabir University in
Tehran. My main research activities have been focused on microstructure- properties correlation
of polymer nanocomposites and nanobiomaterials. I am currently full professor at this department and
published over 90 international papers.
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