Reach Us +1-217-403-9671
Relative Bioavailability Of Oral Insulin Entrapped In Solid Lipid Nanoparticles To Subcutaneously Administered Insulin In Diabetic Rats | 19805
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

5th World Congress on Bioavailability and Bioequivalence Pharmaceutical R&D Summit

Tajdar Husain Khan
Posters: J Bioequiv Availab
DOI: 10.4172/0975-0851.S1.018
C olloidal Drug Delivery Systems have shown to enhance oral bioavailability of proteins and peptides. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral delivery of insulin. Insulin loaded SLN were prepared by double emulsion technique, employing Dynasan 114 as lipid phase and soy lecithin and polyvinyl alcohol as primary and secondary emulsifier respectively. The particle size and zeta potential measured by photon correlation spectroscopy (PCS) were 91?6.12 nm, -36?2.3 mV respectively. SLN observed by scanning electron microscopy (SEM) showed extremely spherical shape. The entrapment efficiency (EE%) and drug loading capacity (DL%) determined with high performance liquid chromatogram (HPLC) were 86.53?0.7 % and 6.11?0.8 %, respectively. Insulin loaded SLN exhibited sustained release in pH 7.4 phosphate buffer and shown to protect insulin from enzymatic degradation in vitro in presence of pepsin and trypsin. The biological activity of insulin loaded SLN was estimated by enzyme-linked immunosorbant assay and in vivo using Wister diabetic rats after oral administration of insulin-loaded SLN to diabetic rats, and a considerable hypoglycemic effect was observed as compared to pure insulin. Insulin loaded SLN showed better protection of insulin from harsh gastro intestinal environment than the insulin solution as evident from Cmax and AUC 196.4 μIUml-1 and 236.5 μIU. versus 16.4 μIUml-1 and 36.6 μ only). The relative pharmacokinetic bioavailability of insulin was enhanced approximately 7 times of pure insulin solution when loaded in SLN (11.4% versus 1.7% only)
Tajdar Husain Khan has completed his PhD in 2006 from Jamia Hamdard, New Delhi, India and currently working as Assistant Professor in Department of Pharmacology, College of Pharmacy, Salman bin Abdulaziz University, Al-Kharj, Saudi Arabia. He has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of repute. His area of expertise is cancer chemoprevention, microwave radiation, and chemical induced toxicity.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version