alexa Release Of Dopamine Encapsulated In A TiO2 Matrix In The Striatum Improves The Motor Activity In Hemiparkinsonism Model Of The Rat
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

9th Annual European Pharma Congress
June 26-28, 2017 Madrid, Spain

Guadalupe Valverde Aguilar, Patricia Vergara Aragon, Martha Chico Vazquez M T A, Monica R Jaime Fonseca and Patricia Santiago Jacinto
CICATA- Instituto Politécnico Nacional, México
Universidad Nacional Autónoma de México, Mexico
Posters & Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689-C1-025
Statement of the Problem: Parkinson´s disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra causing dopamine depletion in the striatum. The purpose of this research was to evaluate the temporal stability of dopamine encapsulated in a titanium dioxide (TiO2) matrix synthesized by sol-gel method under atmospheric conditions. The formation of the oxidation products from dopamine were analyzed by color change of the microimplant, optical absorption and infrared spectroscopy. The evaluation in vivo on the locomotor activity in the open field test of hemiparkinson rat model was studied. Material & Methods: a) TiO2 precursor solution. A mixture of Tetrabutyl orthotitanate and diethanolamine which prevent the precipitation of oxides and stabilize the solutions was obtained with deionized water. Tetraethyleneglycol was added to the above solution under stirring. b) TiO2/DA solution. To 20 ml of TiO2 solution prepared in section (a), the Dopamine was added and the sol was stirred at room temperature under darkness. The states of dopamine oxidation were evaluated using infrared spectroscopy. Forty Wistar rats were divided into 4 groups: Sham, Lx (hemiparkinsonian), Lx + TiO2/DA matrix, and TiO2/DA matrix only. Induced rotation test and locomotor activity task were performed on days 0, 1, 21, 90 days after the insertion of the TiO2/DA in the caudate nucleus. Findings: Results show that the TiO2 matrix can protect the dopamine inhibiting its chemical instability and retarding its oxidation gradually. Less induced rotations and better performance in the locomotor activity during the 90 days of the experimental evaluation suggest that probably dopamine successfully stabilized and it was released from its reservoir in the striatum. Conclusion: Advantages of this treatment are its easy and fast elaboration, low cost and immediate benefits on the motor disturbances presented by the animals with hemiparkinsonismo.

Guadalupe Valverde Aguilar obtained her PhD in Physics (2003) at Institute of Physics, UNAM. Her Post-doctoral stay was made in UCLA, USA for two years. Her research is focused on electrical and optical properties from amorphous and nanostructured sol-gel materials. Her field of research includes photoluminescence, drug delivery, photoconductivity and hydrogen production. She has published 58 papers in international journals.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version