alexa Renal Involvement In Systemic Diseases In Children: Contribution Of Cardiovascular Comorbidity
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

12th Global Nephrologists Annual Meeting
June 26-28, 2017 London, UK

Mohsen Hoshayarikhani, Kazyra I, Abrosimava N and F Fotovatkasbshirazi
Belarusian State Medical University, Belarus
ScientificTracks Abstracts: J Nephrol Ther
DOI: 10.4172/2161-0959-C1-039
Abstract
Introduction: Despite the significant progress achieved in the treatment and outcome of children with renal involvement due to systemic diseases (lupus, vasculitis), many questions remain in the early detection of cardiovascular complications, the leading cause of death in these patients in adulthood. Aim: This study is contributed to find out the risk of developing cardiovascular disease (CVD) in patients with lupus nephritis (LN), IgA Henoch-Schonlein purpura nephritis (HSPN) and ANCA-associated nephritis. Materials: 49 children were enrolled in the study: 24 with lupus (2 boys, 7-17 years, median age 13.8), 21 with HSPN (10 boys, 3-17 yrs, median 10.5) and 4 with ANCA nephritis (2 boys, 7-17 yrs, median 11.8). All patients had morphological verification of the disease. As a control group 37 healthy children were examined. 24 hours monitoring of blood pressure (BP), ECHO-CG, carotid intima media thickness (cIMT), left ventricles mass index (LVMI), relative thickness of left ventricles wall (RTLV), body mass index (BMI), serum lipids levels, serum glucose, serum uric acid, eGFR and markers of vascular endothelial dysfunction VEGF and TGF1β were measured. Results: Arterial hypertension was observed in 35/49 (72%) of children with glomerular diseases. In 21/24 of patients with LN (88%), in 100% of ANCA nephritis and 10/21 HSPN (48%), required of an average 3 hypotensive drugs. Dilatations of the LV in 24%, reduced ejection fraction in 2.1% of all patients were seen. LVMI, RTLV, BMI and cIMT were higher compared with healthy (p<0.05). In patients with nephritis concentration of serum VEGF and TGF1β correlated with AG. The mean serum cholesterol level was 5.8 mmol/l in LN, 6.94 in ANCA nephritis and 5.16 in patients with HSPN (p<0.05), lipoproteins of low and very low density prevailed. The mean serum glucose level was not significantly higher than in healthy, in contrast to the level of uric acid (p<0.05), especially in patients with ANCA nephritis (p<0.01). Conclusions: In patients with LN, HSPN and ANCA-associated nephritis abnormalities in serum lipids level were correlated with disease activity and duration, younger age of diagnosis, mean cIMT, eGFR, increased systolic and diastolic BP, BMI, LVMI, RTLV, concentration of VEGF and TGF1β. Such patients are at high risk of early development of cardiovascular complications requiring early correction.
Biography

Mohsen Hoshyarikhani is currently a 5th year Medical student (of 6-year education) at Belarusian State Medical University. He had 5 international publications in fields of Pediatrics Nephrology and Cardiology, Neurology and Dermatology. He has interests in different fields like Medicine, Pediatrics Nephrology and Cardiology. He is also interested in Pediatrics Neurosurgery, Radiology, Research and Laboratory Studies.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords