alexa
Reach Us +44-1202-068036
Replacing Carbohydrate With Protein And Fat Affects PBMC Metabolites In Prediabetes Or Type-2 Diabetes: Comparison With Plasma Metabolites | 43850
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Replacing carbohydrate with protein and fat affects PBMC metabolites in prediabetes or type-2 diabetes: Comparison with plasma metabolites

5th International Conference and Exhibition on Metabolomics

Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Miso Kang and Jong Ho Lee

Yonsei University, Korea

Posters & Accepted Abstracts: Metabolomics

DOI: 10.4172/2153-0769.C1.032

Abstract
We investigated whether metabolic profiles of PBMC and plasma were affected by decrease in PBMC and plasma lipoproteinassociated phospholipase A2 (Lp-PLA2) activities induced by dietary intervention. 70 nonobese subjects aged 40–70 years (18.5 ≤ BMI < 30 kg/m2) with prediabetes or newly-diagnosed type-2 diabetes were randomly divided according to diet that they consumed; control group (n=35) have a usual refined-rice diet, whole-grain group (n=35) have a diet replaced refined rice with whole grains and legumes. All subject consumed the diet for 3 meals per day during 12 weeks. After 12 weeks invervention, changes in fasting glucose, HbA1c, HOMA-IR index, malondialdehyde, oxidized LDL (ox-LDL), LDL particle size, and plasma and PBMC Lp-PLA2 activity in the whole-grain group were significantly different from those of the control group. The PBMC levels of L-leucine, oleamide, lysoPC (16:0), and lysoPC (18:0) in the whole-grain group showed greater decrease compared to those of the control group. Changes in plasma metabolites were not significantly different between the two groups. Changes in PBMC Lp-PLA2 activity positively correlated with changes in glucose, ox-LDL, and metabolites including L-leucine, oleamide, lysoPC (16:0), lysoPC (18:0). Moreover, Changes in PBMC Lp-PLA2 activity negatively correlated with changes in LDL particle size. This study indicated that dietary intervention affects on PBMC Lp-PLA2 activity and metabolites as compared to those of plasma metabolites in subjects with prediabetic or type-2 diabetes.
Biography

Hye Jin Yoo is a graduate school student in PhD course at Yonsei University. She is woking in Nutrigenetics/Nutrigenomics laboratory, in Department of Food and Nutriton, lead by Prof. Jong Ho Lee. Her research focus is clinical nutrition. She has published 1 paper in reputed journal.

Email: [email protected]

Top