Replacing Carbohydrate With Protein And Fat Affects PBMC Metabolites In Prediabetes Or Type-2 Diabetes: Comparison With Plasma Metabolites | 43850
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
We investigated whether metabolic profiles of PBMC and plasma were affected by decrease in PBMC and plasma lipoproteinassociated
phospholipase A2 (Lp-PLA2) activities induced by dietary intervention. 70 nonobese subjects aged 40–70 years
(18.5 ≤ BMI < 30 kg/m2) with prediabetes or newly-diagnosed type-2 diabetes were randomly divided according to diet that they
consumed; control group (n=35) have a usual refined-rice diet, whole-grain group (n=35) have a diet replaced refined rice with
whole grains and legumes. All subject consumed the diet for 3 meals per day during 12 weeks. After 12 weeks invervention, changes
in fasting glucose, HbA1c, HOMA-IR index, malondialdehyde, oxidized LDL (ox-LDL), LDL particle size, and plasma and PBMC
Lp-PLA2 activity in the whole-grain group were significantly different from those of the control group. The PBMC levels of L-leucine,
oleamide, lysoPC (16:0), and lysoPC (18:0) in the whole-grain group showed greater decrease compared to those of the control
group. Changes in plasma metabolites were not significantly different between the two groups. Changes in PBMC Lp-PLA2 activity
positively correlated with changes in glucose, ox-LDL, and metabolites including L-leucine, oleamide, lysoPC (16:0), lysoPC (18:0).
Moreover, Changes in PBMC Lp-PLA2 activity negatively correlated with changes in LDL particle size. This study indicated that
dietary intervention affects on PBMC Lp-PLA2 activity and metabolites as compared to those of plasma metabolites in subjects with
prediabetic or type-2 diabetes.
Hye Jin Yoo is a graduate school student in PhD course at Yonsei University. She is woking in Nutrigenetics/Nutrigenomics laboratory, in Department of Food and Nutriton, lead by Prof. Jong Ho Lee. Her research focus is clinical nutrition. She has published 1 paper in reputed journal.