alexa Replication Stress Response Defect And Cancer Stemness
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on Cell Science & Stem Cell Research
June 24-26, 2014 Valencia Conference Centre, Valencia, Spain

Shiaw-Yih Lin
ScientificTracks Abstracts: J Cell Sci Ther
DOI: 10.4172/2157-7013.S1.028
Abstract
R eplication stress response (RSR) is a subset of DNA damage response that safeguards the replication process. It has been known that in normal cells, hyperproliferative activity caused by oncogene activation leads to replication stress and to the activation of RSR. The activation of RSR consequently triggers cellular senescence or apoptosis to prevent cell transformation. Recently, my lab has developed a unique cell model to study how normal cells respond when they are simultaneously challenged with oncogenic stress and the loss of RSR. Intriguingly, it was found that these RSR defective cells exhibited many characteristics of cancer stem cells, including possessing cancer stem cell markers and EMT (epithelial-mesenchymal transition). Present work therefore functionally links RSR defect with cancer stemness during the process of cellular transformation.
Biography
Shiaw-Yih Lin?s research efforts are focused within an overall theme of DNA damage response defects in cancer etiology, cancer prevention, cancer detection and targeted therapy. He has worked in these fields for more than 10 years, and has published more than 50 papers. He serves as an editor of International Journal of Cancer Therapy and Oncology and on the editorial boards for World Journal of Clinical Oncology , American Journal of Cancer Research, Frontiers in Molecular and Cellular Oncology, ISRN Cell Biology, World Journal of Translational Medicine, Experimental Hematology & Oncology, and Annals of Translational Medicine. He has served on numerous review committees for NIH, DOD and other funding organizations both nationally and internationally
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords