alexa Results Of A Pilot Clinical Trial Of DC-based Vaccines For Treatment Of HCV-infection
ISSN: 2167-0889

Journal of Liver
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4th International Conference on Hepatology
April 27-28, 2017 Dubai, UAE

Oleynik E A, Leplina O Yu, Kurochkina Yu D, Starostina N M, Ostanin A A and Chernykh E R
Research Institute of Fundamental and Clinical Immunology, Russia
Posters & Accepted Abstracts: J Liver
DOI: 10.4172/2167-0889-C1-012
Abstract
Antigen-specific СD4+ and CD8+T cells play a key role in pathogenesis and outcome of hepatitis C virus (HCV) infection. While the strong multiepitopic T cell responses predict successful viral elimination, a deficiency of adaptive immune response is associated with virus persistence. Dendritic cells (DCs) play a dominant role in T cell priming and maintenance of strong T cell response. The present paper contains results of an open pilot study of efficacy and safety of DC-based vaccines in the patients with chronic hepatitis C. Ten patients with genotype 1 HCV, viral load - RNA ≥10^4 IU/mL, without development to cirrhosis have been enrolled in this study. DCs were applied in 2 rounds of vaccination performed within 7 months. DCs were generated in presence of GM-CSF and IFNα and then loaded with recombinant viral proteins Core (1-120) and NS3 (1192 – 1457) genotype 1b HCV. T cell specific responses to viral antigens and mitogen reactivity to Concanavalin A were evaluated by H3 thymidine incorporation. Th1 and Th2 responses were measured by IFN-ɣ and IL-4 production by antigenstimulated T cells. DC-based vaccines did not induce any serious side effects. Vaccination with Ag-loaded DCs resulted to an increase of proliferative response of mononuclear cells to viral antigens (mostly to Core), an induction of antigen-specific Th1 cells (with a peak response after the second course of vaccinations), restored initially low ConA-stimulated lymphocyte proliferative activity and did not lead to the generation of regulatory CD4+25+127-T cells. Though sustained reduction of viral load has not been achieved, the proliferative activity of mononuclear cells to viral antigens after the 1st course of vaccine negatively correlated with the viral load. The data obtained suggest that DC-based vaccines may be a promising approach to the enhancement of T cell specific immune response in patients with chronic hepatitis C.
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