alexa Reverse Metabolomics - Metabolomics In Drug Discovery: Connecting Metabolomic Profiles With Phylogenetic, Medicinal And Flavoring Properties
ISSN: 2153-0769

Metabolomics:Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Metabolomics & Systems Biology
March 24-26, 2014 Hilton San Antonio Airport, San Antonio, USA

Ludger A Wessjohann
ScientificTracks Abstracts: Metabolomics
DOI: 10.4172/2153-0769.S1.024
Abstract
How can we find out, which compounds in complex matrices, e.g. a plant extract, carries a certain flavoring or medicinal property? How can we do this without either (1) isolating all compounds, or (2) using bioassay guided fractionation. Method 1 requires extensive dereplication, and method 2 is limited to fast assays. Both are unsuitable to cover additive or synergistic effects. Commonly metabolomics, especially in the plant sciences, is used to identify metabolite pattern differences on the basis of changed ?properties?, with properties commonly relating to genetic differences or treated vs. untreated organisms. By reversing this approach, we use metabolite patterns of different organisms to evaluate which properties are correlating with modified metabolite patterns. In order to do so, requirements are different from comparative metabolomics, where precise repetition of processing, e.g. the extraction scheme of a plant, is of importance. In reverse metabolomics, annotation and quantification is more relevant, and different (new) methods of computational evaluation are required. Therefore, we initially compared and developed LC- MS, 1D- and 2D-NMR profiling methods for the secondary metabolome of several medicinal plant species, to relate this to phylogeny and origin (for adulteration ID). In a second step we compared and developed computational methods to correlate the profiles with, e.g., inflammation reduction, cytotoxic (anti-cancer)or antibiotic properties, and to identify the most likely property-relevant group parameters or even single constituents, which will allow selecting the best plants or origins for a desired property like beer bitterness in hops. Eventually the method was successfully transferred to different applications with commercial partners, such as identifying constituent combinations or even single metabolites responsible for antibiotic properties of fungi, anti-Alzheimer activity of algae, or even for the savery steak taste in grilled beef.
Biography
Ludger A Wessjohann studied Chemistry in Germany, UK and Norway, and a postdoctoral fellow (AvH) with Prof. Paul Wender at Stanford University (USA), working on the total synthesis of Taxol ? . After professorships in Munich (D) and Amsterdam (NL), he became director and in 2010 managing director of the Leibniz Institute of Plant Biochemistry, and in parallel holds a chair at the University Halle. He focuses on the analysis, synthesis and application of natural products and derivatives, and has 270 publications and 20 patents. He is co-founder of four companiesand received several honors, e.g. the Microsoft IT Founders Award, honorary membership of the Argentinean Society of Synthetic Organic Chemistry etc.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords