alexa Rheumatoid Arthritis (RA) Specific Therapy With Disease-specific Monoclonal Antibodies
ISSN: 2161-0533

Orthopedic & Muscular System: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference and Exhibition on Orthopedics & Rheumatology
August 19-21, 2013 Embassy Suites Las Vegas, NV, USA

David Naor
Accepted Abstracts: Orthop Muscul Syst
DOI: 10.4172/2161-0533.S1.014
Abstract
C D44 and RHAMM (CD168) are migration-supporting molecules in cancer and inflammatory cells, including synovial fluid cells from RA patients. In addition, CD44 is a transmitter of apoptotic signals. Exploring the human rheumatoid arthritis disease, we have discovered a CD44 variant (designated CD44vRA), that is generated by alternative splicing, and exclusively expressed on joint inflammatory cells of the RA patients. Monoclonal antibodies (mAbs) directed against human CD44vRA (anti-CD44vRA mAbs) bind exclusively to joint inflammatory cells of RA patients and kill them by apoptosis ,whereas peripheral blood leukocytes derived from the same patient remained undamaged when treated with the same antibodies. Anti-CD44vRA mAb injected at the onset of collagen-induced arthritis of DBA/1 mice markedly reduces the joint inflammation, indicating cross-reactivity between the mouse arthritic CD44 and human CD44vRA. We have shown earlier that RHAMM can compensate for CD44 in supporting in vitro cell migration and in vivo joint inflammation, when CD44 is genetically deleted (e.g., by CD44 Knock out). Hence, Injection of anti-RHAMM antibodies at the onset of CIA can also reduce the joint inflammation, but only when CD44 is genetically deleted. The clinical feasibility of anti-CD44vRA and anti-RHAMM mAbs is now under investigations in preclinical studies and part of available conclusions will be discussed.
Biography
David Naor completed his Ph.D. studies in the Hebrew University of Jerusalem and holds research positions, as post doc or visiting professor, in UC Berkley, UCLA and Imperial College, London. At present he is a professor of Immunology in the Faculty of Medicine, the Hebrew University. He published 150 articles, including publications in leading journal such as Nature, PNAS, J Exp Med, J clin Invest and J Immunol . He received award from Johnson & Johnson, in recognition of outstanding research toward the advances of science and technology in health care
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords