Reach Us +447482877761
Ricenet: Genome-scale Multi-level Network Reconstruction Of Rice | 9381
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Ricenet: Genome-scale multi-level network reconstruction of rice

International Conference on Integrative Biology Summit

Ming Chen, Lili Liu, Qian Mei and Zijun Zhang

Accepted Abstracts: J Comput Sci Syst Biol

DOI: 10.4172/0974-7230.S1.004

As one of the world's most important food plants, rice has important syntenic relationships with the other cereal species and is a model plant for the grasses. Genome-scale multi-level network reconstruction is a key step in systemic understanding of the molecule regulatory mechanism in organisms. We integrated protein-protein interactions (PPIs), gene regulations and microRNA-Target interactions into metabolic network and developed the genome-scale multi-level network model of rice, which could provide an available framework for plant genome-scale multi-level network model reconstruction. Firstly, we reconstructed a genome-scale metabolic model (OsaGEM) covering primary metabolism for a compartmentalized plant cell based on the Rice genome. OsaEM is a literature-based, genome-wide metabolic model, which at the moment contains 4,462 function genes, 3,031metabolits involved in 3,316 reactions and the 3,316 reactions compartmentalized into the cytoplasm, mitochondrion, plastid, peroxisome, and vacuole. Gap analysis, flux balance analysis, gene deletion simulate were performed as well. Furthermore, the Protein-Protein interactions (PRIN), gene regulations and microRNA-Target interactions were integrated into the metabolic model. Finally, RiceNet, a database of storing and visualizing the genome-scale multi-level network was constructed. This system-based framework enables the exploration of global phenotypic effects of gene knockouts, gene insertion, and up-/ down- regulation of gene expression.
Ming Chen received his Ph.D. in Bioinformatics from Bielefeld University, Germany, in 2004. Currently he is working as a Professor in Bioinformatics at College of Life Sciences, Zhejiang University. He is serving as an academic leader in Bioinformatics at Zhejiang University. He is a committee member of Chinese societies for ?Modeling and Simulation of Biological Systems?, ?Computational Systems Biology? and ?Functional Genomics & Systems Biology?.