alexa Role Of Bone Morphogenetic Protein-2 In Primary Knee Osteoarthritis
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics
November 03-05, 2014 Embassy Suites Las Vegas, USA

Abeer Kadry El Zohiery, Nadia A El Kadery, Henaz Khaled and Miriam R Bekhit
ScientificTracks Abstracts: J Pharmacogenomics Pharmacoproteomics
DOI: 10.4172/2153-0645.S1.002
Introduction: Many different factors contribute to the onset and progression of OA. The bone morphogenetic proteins (BMPs), that are subsets of the (TGF- ?) superfamily, stimulate production of extracellular matrix components by chondrocytes and have the ability to counteract catabolic cytokines like interleukin 1 (IL-1). Aim of the work: The aim of this study was to investigate the role of plasma BMP-2 in primary knee osteoarthritis and its relation to disease severity. Methodology: The study included 30 patients with primary knee OA and ten apparently healthy matchedindividualsasa control group. Plasma levels of BMP-2, radiological severity of the disease, pain intensity as well as, assessment of functional status using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) were done. Results: Plasma levels of BMP-2 were significantly higher in patients than in control group. Patients with palpable osteophytes have the highest BMP-2 levels. A strong positive correlation was found between plasma levels of BMP-2 and each of: radiological severity, disease duration and WOMAC score. In Conclusion: BMP-2 levels correlate with radiographic severity of OA which make such biomarker measurement may not only act as a substitute marker for the disease, but also has the potential to contribute to the fundamental processes underlying the pathogenesis of OA.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version