alexa
Reach Us +1-504-608-2390
Role Of CXCL4 In Neutrophil Accumulation And Tissue Injury In Severe Acute Pancreatitis | 36102
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Role of CXCL4 in neutrophil accumulation and tissue injury in severe acute pancreatitis

4th International Conference and Exhibition on Immunology

Mohammed Yousif Merza

Lund University, Sweden

ScientificTracks Abstracts: J Clin Cell Immunol

DOI: 10.4172/2155-9899.C1.024

Abstract
Leukocyte infiltration and acinar cell necrosis are hallmarks of severe acute pancreatitis (AP) but the signaling pathways regulating inflammation and organ injury in the pancreas remain elusive. In the present study, we investigated the role of CXCL4 in AP. Male C57BL/6 mice were treated with an anti CXCL4 antibody (20 μ/kg) prior to induction of pancreatitis by infusion of taurocholate into the pancreatic duct. Pretreatment with anti CXCL4 Ab reduced blood amylase levels, pancreatic neutrophil recruitment and hemorrhage and edema formation in taurocholate-evoked pancreatitis. Moreover, administration of anti CXCL4 Ab decreased the taurocholate-induced increase of myeloperoxidase activity in the pancreas and lung. Treatment with anti CXCL4 Ab markedly reduced levels of CXCL2 in the pancreas and IL-6 in the plasma in response to taurocholate challenge. Notably, inhibition of CXCL4 had no direct effect on secretagogue-induced activation of trypsinogen in pancreatic acinar cells in vitro. A significant role of CXCL4 was confirmed in an alternate model of AP induced by L-arginine challenge. Our findings show that CXCL4 regulates neutrophil accumulation and tissue damage via CXCL2 formation in AP. Thus, these results reveal new signaling mechanisms in pancreatitis and indicate that targeting CXCL4 might be an effective way to ameliorate severe AP.
Biography

Mohammed Yousif Merza is a PhD student and permanent staff at Hawler Medical University, Kurdistan. He has graduated from Salahadin University, Hawler in 2003 and completed a Master’s degree at Glasgow University, UK in 2008. He has published 5 papers in reputed journals.

Email: [email protected]

Top