Role Of Epigenetics In The HIF Pathway And Novel Therapeutic Opportunities | 9321
Journal of Computer Science & Systems Biology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Hypoxia plays critical roles in the pathobiology of heart disease, cancer, stroke, eye, and chronic lung disease, which are
responsible for 60% of deaths in the United States. Hypoxia-mediated activation of the hypoxia-inducible-factor (HIF)
pathway, leading to transcriptional changes in gene expressions, plays a fundamental role in the pathobiology of above diseases.
Yet, molecular and biochemical mechanisms governing this fundamental pathway remain poorly understood. Since our initial
identification of first iron(II), 2-oxoglutarate (2OG)-dependent dioxygenase involved in transcription regulation by the HIF
pathway, results from numerous studies have established a key role for these enzymes in epigenetic transcriptional regulation.
Our long term goal is to use our experience in the HIF pathway and dioxygenases/demethylases to delineate their roles in normal
development/ disease states, and identify small molecule modulators that can be used to develop more effective strategies for
therapeutic intervention. We have recently shown that hypoxia induces the expression of a number of histone lysine demethylases/
dioxygenases (KDMs) in cancer and retinal pigment epithelial cells. Moreover, we found that the expression of pro-angiogenic
genes (ADM and GDF15) is dependent on KDMs under hypoxic conditions. Further, treating the cells with a general KDM
inhibitor blocks the expression of these pro-angiogenic genes. Results from our studies suggest that specific inhibitors of KDMs
such as JMJD1A can be a new therapeutic approach to treat diseases caused by the hypoxia.
Mridul Mukherji has completed his Ph.D. at the age of 29 years from the University of Oxford and postdoctoral studies from the Scripps Research
Institute. At present, he holds a rank of Assistant Professor at the School of Pharmacy, University of Missouri-Kansas City. He has
than 26 papers in reputed journals and serving as an editorial board member of Dataset Papers in Biology, Hindawi Publishing Corporation.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals