Role Of Helicobacter Pylori Infection In Processes Of Local Immune Homeostasis In Child?s Gastrointestinal Mucosa: Study In The Far East Of Russia | 19631
Journal of Clinical & Cellular Immunology
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Previously, the author investigated
infection of the adult patients with gastrointestinal diseases in
Vladivostok, far Eastern Russia. In this study, the role of
infection in lactase deficiency pathogenesis in
children was further investigated. In the pediatric fields, secondary and transient lactase deficiency was seen during clinical
practice of different gastrointestinal diseases. Especially, conditions of gastric mucosa and epithelium in different pathogenetic
variants of lactase deficiency in infants and children under 3 years have not been well studied. In this study, the roles of
infection and immune responses of gastric mucosa and epithelium in, pathogenetic aspects of lactase deficiency in
children under 3 years were investigated.
Sixty-three pediatric patients (age: 5 months to 3 years) with different loss of weight in Regional Clinical Center
of Maternity, Vladivostok, Russia, were also included during 2008-2011. All patients were diagnosed as lactase deficiency.
Morphological changes of gastrointestinal mucosa were examined by endoscopy and dark field microscopy.
specimens was detected by immunostaining CD4-, CD8-, CD 68-, CD163-, or CD204-positive immune cells in the specimens
were detected by immunostaining.
In the previous study, 89.9% of patients (age, 15 to 80 years) were H. pylori-positive, regarding the virulence genotype
of H. pylori, 79.4% were cagA-positive. As for EPIYA motif of cagA, ABC type was the most prevalent and accounted for 73.2%;
ABCC type for 14.6%; AB or ABCCC type for 4.9%, and novel AAABC type for 2.4%. No ABD type was detected. In this study,
95% of children under 3 years with secondary lactase deficiency were H. pylori-positive. Changes of immune cell; numbers and
condition in cellular and humoral immunity according to clinical manifestations of this disease were established. Increase of
proliferative activity of immune cells in epithelial layers and the cells without contact to epithelial wall in mucosa were found.
Immunostaining showed the increase of immune cells positive for CD4, CDS, CD 68, CD163, and CD204 in gastrointestinal
epithelium in H. pylori-positive lactase deficiency patients.
In the previous study, cagA-positive
mainly belonged to Western type (EPYIA-ABC type) although
Vladivostok is geographically located in East Asia. Present study is the first investigation of lactase deficiency with
infection in children under 3 years in Vladivostok, Russia. Data suggest mechanisms of pathogenicity of lactase deficiency
infection. The data are also useful for development of immune response algorithm during medication of those
patients and for monitoring of morphological condition of gastrointestinal mucosa in children during various pathologic
processes associated with malabsorption and lactase deficiency. Further investigation is required to reveal the exact mechanisms
of lactase deficiency under
Ivan Reva graduated Vladivostok State Medical University (Russia) in 2000 year. In 2003 had graduated qualification course on basic and urgent surgery on
General Surgery Department of VSMU. In 2004 defend scientific degree in surgical sector. In 2009 had graduated PhD course on the Department of Bacteriology
of Niigata University Graduate School of Medicine. From 2009 until 2012 invited expert at the Department of Bacteriology of Niigata University Graduate School of
Medicine. From 2012 vice-director of the International Medical Education and Research Center (Niigata, Japan) and Senior Research Scientist of the Far Eastern
Federal University (Vladivostok, Russia).
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