alexa Role Of Helicobacter Pylori Infection In Processes Of Local Immune Homeostasis In Child?s Gastrointestinal Mucosa: Study In The Far East Of Russia
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Ivan Reva, T Yamamoto and G V Reva
ScientificTracks Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.017
Abstract
Introduction: Previously, the author investigated H. pylori infection of the adult patients with gastrointestinal diseases in Vladivostok, far Eastern Russia. In this study, the role of Helicobacter pylori infection in lactase deficiency pathogenesis in children was further investigated. In the pediatric fields, secondary and transient lactase deficiency was seen during clinical practice of different gastrointestinal diseases. Especially, conditions of gastric mucosa and epithelium in different pathogenetic variants of lactase deficiency in infants and children under 3 years have not been well studied. In this study, the roles of H. pylori infection and immune responses of gastric mucosa and epithelium in, pathogenetic aspects of lactase deficiency in children under 3 years were investigated. Methods: Sixty-three pediatric patients (age: 5 months to 3 years) with different loss of weight in Regional Clinical Center of Maternity, Vladivostok, Russia, were also included during 2008-2011. All patients were diagnosed as lactase deficiency. Morphological changes of gastrointestinal mucosa were examined by endoscopy and dark field microscopy. H. pylori in biopsy specimens was detected by immunostaining CD4-, CD8-, CD 68-, CD163-, or CD204-positive immune cells in the specimens were detected by immunostaining. Results: In the previous study, 89.9% of patients (age, 15 to 80 years) were H. pylori-positive, regarding the virulence genotype of H. pylori, 79.4% were cagA-positive. As for EPIYA motif of cagA, ABC type was the most prevalent and accounted for 73.2%; ABCC type for 14.6%; AB or ABCCC type for 4.9%, and novel AAABC type for 2.4%. No ABD type was detected. In this study, 95% of children under 3 years with secondary lactase deficiency were H. pylori-positive. Changes of immune cell; numbers and condition in cellular and humoral immunity according to clinical manifestations of this disease were established. Increase of proliferative activity of immune cells in epithelial layers and the cells without contact to epithelial wall in mucosa were found. Immunostaining showed the increase of immune cells positive for CD4, CDS, CD 68, CD163, and CD204 in gastrointestinal epithelium in H. pylori-positive lactase deficiency patients. Discussion: In the previous study, cagA-positive H. pylori mainly belonged to Western type (EPYIA-ABC type) although Vladivostok is geographically located in East Asia. Present study is the first investigation of lactase deficiency with H. pylori infection in children under 3 years in Vladivostok, Russia. Data suggest mechanisms of pathogenicity of lactase deficiency under H. pylori infection. The data are also useful for development of immune response algorithm during medication of those patients and for monitoring of morphological condition of gastrointestinal mucosa in children during various pathologic processes associated with malabsorption and lactase deficiency. Further investigation is required to reveal the exact mechanisms of lactase deficiency under H. pylori infection.
Biography
Ivan Reva graduated Vladivostok State Medical University (Russia) in 2000 year. In 2003 had graduated qualification course on basic and urgent surgery on General Surgery Department of VSMU. In 2004 defend scientific degree in surgical sector. In 2009 had graduated PhD course on the Department of Bacteriology of Niigata University Graduate School of Medicine. From 2009 until 2012 invited expert at the Department of Bacteriology of Niigata University Graduate School of Medicine. From 2012 vice-director of the International Medical Education and Research Center (Niigata, Japan) and Senior Research Scientist of the Far Eastern Federal University (Vladivostok, Russia).
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords