alexa Role Of HIV-1 Nef In Acceleration Of HCV-mediated Liver Disease Progression
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on HIV/AIDS, STDs, & STIs
October 27-29, 2014 Embassy Suites Las Vegas, USA

In-Woo Park, Yan Fan, JinfengLiu, Linden Green and Johnny J He
ScientificTracks Abstracts: J AIDS Clin Res
DOI: 10.4172/2155-6113.S1.006
Abstract
The precise molecular mechanisms on how HIV-1 co-infection accelerates HCV-mediated liver disease progression are currently unknown. Our data showed that infectious HIV-1 virus particles failed to enter into human hepatocytic cell lines, and discernible virus replication was not observed, even when the hepatocytes transfected with HIV-1 proviral DNA were co-cultured with Jurkat T cells, suggesting that liver deterioration in the co-infected patients is not due to the replication of HIV-1 in the hepatocytes. Instead, HIV-1 Nef protein can be transferred from Nef-expressing or HIV-1-infected cells to hepatocytes through conduits, not exosomes, and the transferred Nef in the target hepatocytes altered lipid droplet formation, up-regulated subgenomic replicon expression of HCV, augmented reactive oxygen species (ROS) production, and enhanced ethanol-mediated up-regulation of HCV replication. Taken together, these data indicate that HIV-1 Nef plays an integral role in expedition of liver pathogenesis in the HIV-1/HCV co-infected hosts.
Biography
In-woo Park is currently working as Associate Professor in department of Cell Biology and Immunology, UNTHSC (University of North Texas Health Science Center). 2011 - 2013 Research Associate Professor Cell Biology and Anatomy, UNTHSC, 2007 - 2011 Research Assistant Professor Microbiology and Immunology, Indiana Uni. Sch. of Medicine, 1996 - 2007 Instructor Experimental Medicine, Harvard Medical School. He is also a member of Radiation Safety Committee.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords