enovascular disease (RVD) is an important cause of end stage renal disease and conveys a significant risk of mortality.
Optimal management of patients with RVD and renovascular hypertension (RVH) is a matter of considerable controversy,
as recent studies have failed to show that percutaneous transluminal angioplasty improves renal outcome in patients with RVH.
Both local and systemic inflammation has been linked to morbidity and mortality in patients with RVH. Mechanisms underlying
this association have not been adequately defined. We have established a murine model of RVH employing placement of a
tetrafluoroethylene cuff on the right renal artery.
imaging studies demonstrate that renal blood flow is reduced by 70%
in this model. The right kidney maintains its size for approximately one week. By histopathologic analysis, there are minimal
alterations in the stenotic kidney (STK) at 3 days following surgery. After one week, the STK develops progressive atrophy, a
process that is associated with the influx of CD3+ T cells and F4/80+ macrophages. By qPCR analysis, CCL2 (MCP-1) is rapidly
(within 3 days) induced, prior to the influx of inflammatory cells. CCL2 expression was increased after 7 days in infiltrating CD90+
T cells and CD11b+ macrophages isolated from renal cortex by immunomagnetic separation. Inhibition of CCL2 signaling by
RS-102895 prevented T cell and macrophage infiltration into the STK and significantly reduced renal atrophy. We conclude that
CCL2 may provide a therapeutic target for preventing inflammation and development of atrophy in RVH
Joseph P. Grande received his M.D. and Ph.D. degrees from the University of Chicago and post-doctoral training at the University of Michigan. He
is currently a Professor of Laboratory Medicine and Pathology at Mayo Clinic and has over 20 years experience as a clinical and experimental renal
pathologist. He has published more than 200 manuscripts on basic, clinical, and translational studies related to progression of
renal and vascular diseas
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals