Role Of Inflammatory Biomarkers In Chronic Obstructive Pulmonary Disease | 48676
Journal of Pulmonary & Respiratory Medicine
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Purpose: Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. There is a need for biological markers
for better evaluation of patients with COPD. We tested the hypothesis that elevated levels of inflammatory biomarkers fibrinogen,
C-reactive protein (CRP) and leukocyte count (WBC) in individuals with stable COPD are associated with an increased risk of
Patients and methods: Ninety-eight COPD patients diagnosed and classified as COPD and 30 age and gender matched healthy
subjects with normal pulmonary function were observed. Patient follow-up was performed to evaluate the strength of the associations
between inflammatory biomarker levels and future outcome.
Results: Inflammatory biomarkers increase with exacerbation compared to the remission state, mean WBC, CRP and fibrinogen
at 12.212×109/L, 39.462 mg/L and 5.09 g/L in exacerbation respectively compared to 7.877×109/L, 4.142 mg/L and 2.299 g/L in
remission with P values <0.001, <0.001 and <0.004, respectively. Statistically significant correlation was noticed between the levels of
fibrinogen and the % predicted FEV1 (r=0.209, P=0.038) however CRP and WBC did not correlate with % predicted FEV1 (r=_0.031,
P=0.765) for CRP, and that for WBC (r=0.125, P=0.221).
Conclusion: Elevated levels of CRP, fibrinogen and leukocyte count in individuals with COPD were associated with increased
Clinical Implications: Inflammatory biomarkers hold promise for improving the understanding of the complex mechanisms
propagating COPD exacerbation. Fibrinogen in particular has emerged as a potentially useful biomarker and requires further
Ola Alkady completed education at Sohag University in Egypt. Currently researching on Chronic obstructive pulmonary disease (COPD) is a multicomponent disease.