alexa Role Of Minimal Panel Immunostaining In Accurate Diagnosis Of Lung Cancer Using Small Biopsies
ISSN: 2161-1076

Surgery: Current Research
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13th International Conference on Surgical Pathology & Practice
March 27-28, 2017 Madrid, Spain

Manar Ahmed Abdel Rahman, Nadia Abdel Moneim Nada, Khaled Refaat Zalata, Mohammad Khairy El Badrawy, Iman Mohammed El Salkh and Amr Abdel Hamid
Mansoura University, Egypt
ScientificTracks Abstracts: Surgery Curr Res
DOI: 10.4172/2161-1076.C1.029
Introduction: In small biopsies standard morphology cannot specifically subtype the tumor. Histologic subtyping of lung cancer is mandatory for treatment. Immunohistochemical staining is a valuable tool for diagnosis of lung cancer. Aim: The aim of this study was to evaluate the diagnostic accuracy of minimal panel of Napsin A, CK 5/6 and CD 56 versus H&E of lung cancer in small biopsies. Methods: 84 small sized tissue samples were obtained. 70 samples were obtained via fiberoptic bronchoscope (FOB) and 14 samples were obtained with transothoracic CT guided tru-cut needle. All samples were stained with H&E for morphologic diagnosis, then the same samples were stained with immuno- histochemical (IHC) staining including 3 antibodies (Napsin A, CK 5/6 and CD 56), then we compared the diagnostic yield of both methods. Results: After H&E staining, according to WHO 2004 classification: 40 cases were adenocarcinoma (AC), 10 were squamous cell carcinoma (SCC), 22 were large cell carcinoma (LCC) and 12 were neuroendocrine tumors (NET). After IHC: According to WHO 2015 classification, 54 (64.3%) were AC, 11 (13.1%) were SCC. 11 (13.1%) were NET and 8 (9.5%) were Non-Small Cell Lung Cancer NSCLC (Counterpart of large cell carcinoma in 2004 WHO classification). Napsin A was expressed in 98% (53/54), CK 5/6 in 90.9% (10/11) of SCC and CD 56 in 100% (11/11) of neuro- endocrine tumors. Conclusion: IHC with Napsin A, CK 5/6 and CD 56 has a more diagnostic value in precise typing of different cell types of lung cancer than H&E in small biopsies.

Manar Ahmed Abdel Rahman is currently working as Faculty of Medicine at Mansoura University, Egypt. She received a Doctoral Degree (PhD) in Pathology from Mansoura University, Egypt in the 2016, followed by M.Sc. from the same university.

Email: [email protected]

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