Role Of Sympathetic Nervous System In Rat Ovarian Ageing | 45953
Journal of Biosensors & Bioelectronics
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At present, women have delayed motherhood after 30 years. From this age, the problems of fertility arise and the success percentage
of in vitro fertility programs declines. Then, it is important to know the mechanisms involved in the ovarian aging in this
period. One of the mechanisms involving in the ovarian aging is the increased sympathetic nerve activity (SNA). In turn, it has been
described that the ovary of women post menopause has a higher density of nervous fibers as compared with age-matched control
women. We have demonstrated that a rat reproductive aging has also an increased ovarian SNA, which is strongly correlated with
the spontaneous appearance of follicular cysts, decreased ovulation and loss of preantral follicles in the ovary. The relevance of these
findings was that they have a direct clinical application. The adrenergic receptors present in the ovary are mostly of the β2-adrenergic
receptors subtype and noradrenaline exert their effect through them, modifying follicular development and steroid secretions being
an increased activity associated with formation and maintenance of cystic structures. Blockade of β-adrenergic receptors recovered
ovarian function during reproductive aging. Besides, the successful use of electro acupuncture procedures (decrease SNA) both
in rats and patients permit the recovery of ovulatory cycles and ovarian function. The highest sympathetic innervation found in
postmenopausal women suggests that have a correlation between the infertility by ageing and by activation of sympathetic nerves.
The control of the sympathetic activity could expand out of the window of subfertility and it could promote successful fertility
program in ageing woman.
Maritza P Garrido is a young academic researcher who works in Endocrinology and Reproduction Biology Lab of the Jose Joaquin Aguirre Clinical Hospital, pertaining to the University of Chile. She collaborates with the Medicine, Chemical Sciences and Pharmaceutics Schools of the same university, teaching and participating in the development research projects. She is Biochemist and MSc from the same university and currently attends her Pharmacology PhD studies in the same institution.