alexa Role Of The Polyscaccharide Capsule In Bordetella Pertussis Virulence: A Novel Capsulemediated Virulence Mechanism In A Bacterial Pathogen
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Congress on Bacteriology & Infectious Diseases
November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Sylvie Alonso
ScientificTracks Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.002
Abstract
Polysaccharide capsules are important virulent determinants for many bacterial pathogens by providing various protective mechanisms against hostile extracellular environments. Bordetella pertussis, the causative agent of whooping cough, produces a microcapsule at its surface but its role in pertussis pathogenesis remained to be investigated. In this work, we demonstrate that the proteins involved in the polysaccharide export across the bacterial envelope, but not the surface-exposed capsule itself, are involved in B. pertussis virulence. Absence of KpsT, a membrane-associated protein involved in the polysaccharide transport resulted in the down-modulation of a large number of virulence genes which correlated with strong attenuation in vivo. Mechanistically, we provide experimental evidence of a crosstalk between the polysaccharide export machinery and the two-component system BvgA/S which modulates the expression of the great majority of B. pertussis virulence genes in response to environmental stimuli. Our work unravels a novel capsule-mediated virulence mechanism in the bacteria kingdom.
Biography
Sylvie Alonso obtained a Ph.D. degree in Cellular and Molecular Biology from the University Claude Bernard Lyon I (France). As a post-doctorate fellow at the Pasteur Institute of Lille (France) and Cornell University (Ithaca, USA), she investigated the mechanisms involved in the pathogenesis of Bordetella pertussis and Mycobacterium tuberculosis. She then joined National University of Singapore (NUS) in 2004 in the Department of Microbiology, Yong Loo Lin School of Medicine. She is also a member of the Immunology Programme. Her current research focuses on hostpathogen interactions during bacterial (M. tuberculosis and B. pertussis) and viral (Dengue, Enterovirus 71) infection.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords