alexa Ruthenium-based Anti-cancer Compounds: Insights Into Their Uptake Mechanisms And Cellular Targets | 22665
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Fernanda Marques, Leonor C?rte-Real, T?nia Morais, Maria Helena Garcia, Ant?nio Matos and Manuel Bicho
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
Ruthenium compounds have shown highly promising anticancer activity and may provide a less toxic and more effective alternatives to platinum-based chemotherapies. Many different ruthenium compounds have been tested for their anticancer properties, however without enough investigation into their mode of action. With the aim to give a contribution to elucidate their mechanism of action we studied a set of structurally related Ru(η5-C5H5) complexes with bidentate N,N?-heteroaromatic ligands as prospective metallodrugs, with focus on exploring the uptake, cell death mechanisms and potential cellular targets. These complexes enter the cells by a temperature-dependent process, probably facilitated by binding to plasma transferrin, present high anti proliferative efficacy in a broad range of tumor cells, preferential localization at the cell membrane and cytosol and the ability to inhibit a lysosomal enzyme, acid phosphatase, in a dose-dependent mode. We have extended these studies to examine the potential of these complexes to target cancer cell metabolism, the energetic-related phenotype of cancer cells. The reliance of glycolytic cancer cells on trans-plasma-membrane electron transport (TPMET) systems for their continued survival raises the question of their appropriateness as a target for anticancer drug development strategies. The results from this study indicated that these ruthenium complexes can inhibit lactate production and TPMET activity in a way dependent on the cancer cell aggressiveness and the concentration of the complexes. In vivo antitumor activity of these complexes in a prostate tumor animal model is underway.
Biography
Fernanda Marques is graduated in Chemical Engineering from Instituto Superior T?cnico, Universidade de Lisboa and has a PhD in Biochemistry from Faculdade de Ci?ncias, Universidade de Lisboa. She is a Scientific Researcher at Centro de Ci?ncias e Tecnologias Nucleares, Instituto Superior T?cnico, Universidade de Lisboa, a Nuclear Tecnological Institute for Research. During the last ten years, she has been involved in the biological evaluation of (radio)metal-based compounds as potential therapeutic agents. She has published more than 50 papers in reputed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version