IVS5N+5 G>A polymorphism has been proposed to be
involved in response to antiepileptic drugs (AEDs) in epilepsy, but research data have
been inconclusive. Th
e purpose of the current study was to investigate the association
IVS5N+5 G>A polymorphism and response to AEDs in a cohort
study and a meta-analysis.
IVS5N+5 G>A locus was genotyped in 643 epilepsy
patients (47% drug-resistant) who were on carbamazepine (CBZ) or sodium valproate
(VPA) monotherapy and 564 controls. Meta-analysis of 1486 subjects (528 of whom
were drug-resistant) from related studies, including this cohort study, was performed
under alternative genetic models.
Data from study of the tri-ethnic Malaysian patients indicated that the G
allele carriers in the Indians and Malays with generalized seizure were more resistant
to VPA than the A allele carriers. Moreover, Malay patients with GG genotype and
ected by idiopathic generalized epilepsy (IGE) were more prone to VPA resistance
compared to other genotypes. However, meta-analysis did not show any allelic and
genotypic association with response to AEDs under alternative genetic models.
Our study indicated that the G allele was a risk factor for resistance
to VPA in the Indians and Malays with generalized seizure. Malays with IGE and GG
genotype were more resistant to VPA. However, meta-analysis data did not verify any
association of this locus with response to AEDs
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