alexa Search For New Anti-TB Leads: Green Synthesis And Evaluation Of Antitubercular Activity
ISSN: 2161-0401

Organic Chemistry: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Summit on Past and Present Research Systems of Green Chemistry
August 25-27, 2014 Hilton Philadelphia Airport, USA

Babita Tanwar, Pardeep S Jadhavar and Asit K Chakraborti
Accepted Abstracts: Organic Chem Curr Res
DOI: 10.4172/2161-0401.S1.005
Abstract
Tuberculosis (TB) remained as the major global health problem. Multi-drug resistant (MDR) strains and HIV co-infection are the greatest challenges to treat this disease. The severity of the problem has further accentuated due to the observation of extremely drug resistance (XDR) TB. The MDR and XDR TB, strains are not only resistant to the front-line drugs isoniazid and rifampicin, but also to the number of second-line drugs. These resulted in resurgence in research activities to address the urgent need for new anti-tuberculosis drugs. 1,2-Diamine moiety is present in various biologically active molecules, are important building blocks for the synthesis of various drug intermediates, and serve as ligand in asymmetric catalysis. Ethambutol is one of the diamine-based first line anti-TB drug. Recently, SQ109 (N-geranyl-N-(2-adamantyl) ethane-1,2-diamine) has been reported to be highly potent against the H37Rv and MDR strains of M. Tb. and is in phase-II clinical development. In view of the prevalence of TB amongst the economically underprivileged section of the population worldwide the development new therapeutics with affordable price becomes highly imperative. Thus search of small molecular entity with lesser structural complexity and ease of preparation following greener synthetic routes becomes a mandate for anti-TB new drug development programme. In the context of greener synthetic routes the water-assisted/mediated synthesis is one of the top priority agenda. The use of water as a reaction medium address adequately the aspect of maintaining greenness and the unique physical and chemical properties of water increase the reactivity/selectivity often unattainable in organic solvents. Efforts have been directed towards this direction from this laboratory through development of new and green synthetic protocols. The present study highlights the synthesis of 1,2-diamines, representing the pharmacophoric feature of the 1,2-diamine-based anti-TB drugs, in aqueous medium and evaluation of their anti-tubercular activity that resulted new leads.
Biography
Babita Tanwar has completed MTech Pharma in Pharmaceutical Technology Bulk Drug from National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab and currently pursuing PhD programme (SRF) since 2011 under the guidance of Dr. Asit K Chakraborti in the Department of Medicinal Chemistry, NIPER, Mohali, Punjab, India. She has filed an Indian Patent (Application No.3741/DEL/2013) on ?An improved green protocol for the synthesis of 1,2-diamines via ring opening of aziridines with amines.?
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords