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The analgesic potential of Leea indica (Burm. f.) Merr., a Bangladeshi tribal medicinal plant was studied for the first time. The
crude ethanol extract of Leea indica (Burm. f.) Merr. leaves was evaluated for its central nervous system (CNS) depressant
effect using rodent behavioral models, such as hole cross, open field and thiopental sodium induced sleeping time tests for its
sedative properties and an elevated plus-maze (EPM) test for its anxiolytic potential, respectively. The ethanol extract of L. indica
at doses of 200 mg/kg, p. o., displayed a dose-dependent suppression of motor activity, exploratory behavior (in hole cross and
open field tests) and prolongation of thiopental induced sleeping time in mice. In the EPM test, the dose of ethanol extract
significantly (p < 0.05) increased exploration to and time spent by the treated mice in EPM open arms in a dose dependent
manner. In addition, analgesic potential of L. indica was evaluated for centrally acting analgesic property using formalin induced
licking response model and peripheral pharmacological actions using acetic acid-induced writhing test. In acetic acid-induced
writhing test, all extracts at 200 mg/kg dose exhibited significant (p < 0.05) reduction of writhing response in a dose dependent
manner; in formalin induced licking response model a significant (p < 0.05 - 0.001) result was comparable to the standard drug
diclofenac sodium. These results provide in vivo evidence that leaves of L. indica in general have significant sedative and analgesic
Keywords: Neuropharmacology, open field, elevated plus-maze (EPM), medicinal plant, L. indica, analgesic.
Mr. Talha Bin Emran has been working as a Lecturer, in the Department of Pharmacy, BGC Trust University, Bangladesh from January 2012 to till
the date. Mr. Emran has published more than 20 research and review papers in reputed International and national Journal. He participated in many
seminars and conferences in home to present his research activities. His research work based on Phytochmistry, Pharmacology, Molecular biology,
Oncology and Bioinformatics. He is a fellow of Academy of General Education, India (FAGE) and a fellow of Ministry of Science, Information &
Communication Technology (MOSICT) in the Session 2011-2012 for MS Thesis. He is a life member in Graduate Biochemist Association (GBA) and
also a life member of Association of Pharmacy Professionals (APP), India. He is interested in Clinical Research, Protein Engineering, Immunology
and Molecular Medicine.
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