Serum Creatine Kinase Activity And Monocyte Counts Are Increased In Acute Myocardial Infarction, But Not In General Infection Patients | 16620
Journal of Clinical & Experimental Cardiology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Biomarkers specificity is an important factor for their reliable utilization. Known markers for acute myocardial
infarction (AMI) including creatine kinase (CK) activity, C-reactive protein (CRP) level and blood cell counts are thought to be
altered in other pathological conditions such as infections.
We recruited 15 AMI patients, 15 patients with bacterial infections (infected control group) and 35 normal Subjects.
Peripheral blood samples were obtained for blood cell counts and biochemical analyses.
We therefore compared these biomarkers in 15 AMI patients (troponin criteria > 0.100 ng/mL) and 15 infected controls
with respect to 35 normal subjects. Only monocytes were significantly increased in AMI patients (0.793*109/L) than normal
controls (0.497*109/L). Infected controls showed a significant increase in total WBC (11.50*109/L versus 6.149*109/L) and
neutrophils (9.360 versus 3.223*109/L) counts and significant decrease in RBC (3.750 versus 5.105*1012/L) counts as compared
to normal controls. Serum CK activity was significantly increased in AMI patients (313.20 ? 94.84 U/L) and decreased in infected
controls (48.40 ? 10.35 U/L) as compared to normal controls (100.82 ? 8.86 U/L). The levels of CRP were significantly higher
in infected controls (136.93 ? 34.83 mg/L) and non-significantly higher in AMI patients (38.53 ? 12.76 mg/L) than normal
controls (3.48 ? 0.59 mg/L). Monocytes were significantly correlated with both CK activity and CRP level, however there was no
correlation between CK activity and CRP level.
Differential trends of monocytes and CK activity in AMI and infective controls point towards their possible
application in prognosis of AMI patients. (Supported by National Plan for Science and Technology, King Saud University Project
Alhomida has completed his Ph.D. in 1993 from the University of Akron, Ohio, USA and have joined King Saud University, Department of Biochemistry, College
of Science, Riyadh, Saudi Arabia since 1994. In 2002-2006 he became the Chairman of the Department of Biochemistry and in 2010-2012 he became the Vice-
Dean of Graduate Studies and Scientific Research. He has published more than 95 papers in reputed journals and has been serving as an Editor-in-Chief of Saudi
Journal of Biological Sciences and as editorial board member of repute.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals