alexa Serum TRAF-1 As A Biomarker For Developing Clear Cell Renal Cell Carcinoma
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th International Conference on Biomarkers & Clinical Research
April 15-17, 2014 St. Hilda’s College - University of Oxford, UK

Retnagowri Rajandram, Ning Yi Yap, Jayalakshmi Pailoor, Azad H. A. Razack, Keng Lim Ng, Christudas Morais and Glenda Gobe
ScientificTracks Abstracts: J Mol Biomark Diagn
DOI: 10.4172/2155-9929.S1.021
Abstract
Background and Aims: Renal cell carcinoma (RCC) serum biomarkers, that effectively identify the developing cancer non- invasively, are urgently needed. Tumour necrosis factor receptor-associated factor-1 (TRAF-1) is strongly expressed in the proximal tubular epithelium of normal kidney. The proximal tubular epithelium is thought to be the tissue of origin of clear cell RCC (ccRCC), the most common of the RCC subtypes. The TRAF-1 signalling pathway is necessary for immune response and apoptosis regulation. We have found TRAF-1 is significantly decreased in ccRCC, but no serum analyses had been carried out. The aim of this study was to compare tissue TRAF-1 levels with serum levels in control and ccRCC patients from the University of Malaya Medical Centre (UMMC). Methods: Immunohistochemistry with automated batch staining, and Aperio Image Scope morphometry were used to compare TRAF-1 in 69 ccRCC patients from UMMC with paired normal kidney tissue from those patients. Serum from 15 ccRCC and 15 healthy people were tested for TRAF-1 (ELISA). ANOVA with Tukey?s post-hoc (tissue) and Mann-Whitney U-test (serum) was used (mean ? SEM). Results: Compared with normal kidney (168512 ? 6166 positive pixel counts/PPC), ccRCC was lower (82591 ? 5646 PPC) (p<0.05). However, TRAF-1 in serum from ccRCC patients was significantly increased over normal serum levels (202.28 ? 74.58 vs 50.63 ? 13.56 ng/ml; p=0.012). Conclusion: To the best of our knowledge, this is the first study to evaluate serum TRAF-1 levels in patients with ccRCC. Serum TRAF-1 levels were significantly elevated in patients with ccRCC compared with healthy individuals. The increased serum TRAF-1, compared with decreased tissue TRAF-1 in ccRCC, may indicate the protein is actively secreted from developing ccRCC. As such, serum TRAF-1 may be a useful addition to biomarker panels as a non-invasive indicator of ccRCC development.
Biography
Retnagowri Rajandram completed her B.Sc (Hon I) then her Ph.D. with University of Queensland Australia in 2009 at age 25. She is currently a Senior Lecturer with University of Malaya in Malaysia where she is from. She is an upcoming researcher and is keen in cancer research specifically kidney cancer from her honours year. Her broad interest in this field encompasses the investigation of a possible panel of biomarkers for the disease. Her skills comprise of cell culture work including transfections, western immunblotting, RNA and tissue microarray, immunohistochemistry as well as using Aperio image software. Her current research consist of investigating tumour necrosis factor associated factor 1?s (TRAF1) role in renal cell carcinoma (RCC) using human paraffin embedded tissue and blood from RCC subjects. Her other projects in this area include further defining the molecular pathway of TRAF1 in renal cell carcinoma. She has presented her work at local and international conferences, ever since 2005
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

env[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords