alexa SHBG (TAAAA)n Repeat Polymorphism In South Indian Women With Polycystic Ovary Syndrome
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Pediatrics & Gynecology-2012

Deepika.M.L.N, Ranjith.K, Usha Rani V and Jahan P
Accepted Abstracts: J Pediatr Therapeut
DOI: 10.4172/2161-0665-S1.013
Abstract
PCOS is a common endocrine disorder affecting 4-12% of women worldwide. It is characterized by polycystic ovaries on ultrasound scan, chronic anovulation and hyperandrogenism. The cause of PCOS is unknown; however recent genetic association studies have indicated that a number of genes have been implicated. Some of these genes are involved in the availability of androgens to target tissues or genes determining androgenic activity at the molecular level. Literature revealed the association of Sex Hormone Binding Globulin gene with lower SHBG levels and increased risk for PCOS with clinical features of hyperandrogenism. Th e aim of the current study was to investigate whether there is an association between SHBG (TAAAA)n repeat polymorphism and PCOS. Anthropometric measures revealed significant difference with respect to BMI and W/H ratio between the groups. Genotype analysis revealed eight SHBG(TAAAA)n alleles with 6?13 repeats, present in both PCOS and controls. The distribution of alleles was dissimilar when the alleles were categorized into short (≤8) long (>8) allelic groups. Further, taking into consideration that the majority of the control group were lean women (BMI<25kg/mt2), we assigned PCOS women into lean and overweight-obese PCOS (BMI>25kg/mt2). The distribution of alleles in the lean group revealed no significant difference between short (53% vs 49%) and long (47% vs 51%) alleles. However, statistically significant difference was observed with respect to short (62% vs 44%) and long (56% vs 38%) alleles in the overweight-obese group. The significance of the study will be discussed.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version