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|Sumin Ha, Hojeong Jeong, Ginyung Jeong, Geutae Kim1and Gi Dong Han|
|1Department of Food Science and Technology, Yeungnam University, Gyeongsan, Republic of Korea|
|Posters & Accepted Abstracts: J Exp Food Chem|
|Acute alcohol intake causes multiple organ damages such as severe acute gastrointestinal, liver and cardiovascular diseases. In present study, the gastro protective effects of sigumjang meju (fermented barley bran) water extract (SME) on experimental model of ethanol (EtOH)-induced gastric ulcer in mice. The gastro protective activity of SME was evaluated by gross/histopathological inspection, pro-inflammatory cytokine, and EtOH absorption from stomach. SME pretreatment is characterized to less gastrointestinal bleeding and reduced EtOH absorption into the bloodstream via gastro mucosal barrier. Furthermore, the SME effectively reduced the expression of pro-inflammatory mediator of TNF induced by EtOH. These results indicate that SME prevents gastric mucosal damage induced by acute EtOH administration in mice through the protective effects of SME for anti-inflammatory activities and less absorption of EtOH from stomach.|
Ha Sumin is working at the Department of Food Science and Technology, Yeungnam University, Gyeongsan, Republic of Korea.
Email: [email protected]
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