Mesenchymal stem cells (MSCs) are primordial cells that produce skeletal muscle cells,
the blood, vascular, and urogenital systems and connective tissues in the body. MSCs are of
interest because of their multiple roles in the body. In addition to their ability to diff
into mesenchymal tissues, they support hematopoiesis and can contribute to the homeostatic
maintenance of many organs. Th
e genetic programs controlling the stem cell state are strictly
linked to regulation of cell cycle. Nevertheless, the analysis of which molecules participate in
cell cycle regulation of several stem cell lineages is not exhaustive.
e Retinoblastoma gene family, RB1, RB2/P130 and P107, has a major role in controlling
the G1/S transition through regulation of the E2F family of transcription factors. In addition,
this protein family plays a role in regulating other cellular processes, such as diff
senescence. Nowadays, it is clear that the role of Rb1, Rb2/p130 and p107 depends on several
parameters, such as animal species under investigation; cell type; cell status. Several studies
lack of comparative analysis among the three Retinoblastoma family members. Moreover, their
functions in the MSC biology remains largely uncharacterized.
We decided to analyze the role of these proteins in MSCs? functions since the mechanisms
that regulate the relative quiescence of MSCs and its association with self-renewal and cell
commitment are unclear, as is the contribution of molecular regulators of the cell cycle to these
decisions. Understanding the mechanisms that govern these transitions will provide important
insights into cell-cycle regulation of MSCs and possible therapeutic approaches of MSCs
Umberto Galderisi has completed his Ph.D at the age of 27 years from University ?Federico II? of Naples, Italy.
He did his postdoctoral at Second University of Naples (Italy), at Thomas Jefferson University of Philadelphia
(PA) and at MNHF of Paris, France. Currently he is Associate Professor of Molecular Biology at Second
University of Naples and Adjunct Associate Professor at Temple University in Philadelphia (PA). He is Director
of Stem Cell Research Activities of the Human Health Foundation Onlus (HHF), an Italian charity for basic
medical research supported by the Banca Popolare di Spoleto, located in Terni, Umbria (www.hhfonlus.org).
He is the President and Founder of the Stem Cell Research Italy, the
rst Italian Scienti
c Association, which
gathers Italian scientists involved in stem cell researches. He has published more than 70 papers in reputed
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