alexa Simplet Is Required For Nuclear Localization Of Beta-catenin And For Progenitor Cell Proliferation And Patterning During Zebrafish Early Embryogenesis And Tissue Regeneration
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on Cell Science & Stem Cell Research
June 24-26, 2014 Valencia Conference Centre, Valencia, Spain

Christopher L Antos, Caghan Kizil, Beate K?chler, Jia-Jiun Yan, G?nes ?zhan-Kizil, Enrico Moro, Francesco Argenton, Michael Brand and Gilbert Weidinger
ScientificTracks Abstracts: J Cell Sci Ther
DOI: 10.4172/2157-7013.S1.028
Abstract
T issue formation and regeneration requires the coordinated contribution of stem and progenitor cells that proliferate and pattern. We show that the gene simplet (smp) is required for both proliferation and patterning of progenitor cells in the blastemas of regenerating zebrafish fins. Furthermore, we determined that Simplet/Fam53B (Smp) is required for Wnt- signaling by positively regulating beta-catenin nuclear localization. In zebrafish embryos, the loss of smp blocks the activity of two beta-catenin-dependent reporters and endogenous target genes as well as precludes nuclear accumulation of beta- catenin. Conversely, overexpression of smp enhances beta-catenin nuclear localization and transcriptional activity. Expression of a mutant Smp protein lacking its nuclear localization signal reveals that the translocation of Smp into the nucleus is essential for beta-catenin-dependent Wnt signaling. We further provide evidence that beta-catenin and Smp interact and that Smp retains beta-catenin in the nucleus. In the mouse intestine, the SMP protein localizes to the crypt cells, which are a pool of stem and progenitor cells that are highly dependent on Wnt signaling. Our findings identify a previously unknown, evolutionary conserved regulator of beta-catenin-dependent Wnt signal transduction that is involved in the regulation of stem and progenitor cells
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords