Journal of Chromatography & Separation Techniques
Open Access

Simultaneous determination and validation of telmisartan and amlodipine in pharmaceutical preparations using capillary electrophoretic method

World Congress on Chromatography

September 21-23, 2016 Amsterdam, Netherlands

Ebru TURKOZ Acar, Hayati CELiK, Sevinc KURBANOGLU, Mehmet GUMUSTAS and Sibel A OZKAN

Yeditepe University, Turkey
Ankara University, Turkey

Posters & Accepted Abstracts: J Chromatogr Sep Tech

Abstract :

Cardiovascular diseases (CVDs) are the disorders of heart and blood vessels and primarily include coronary heart disease, hypertension, cerebrovascular disease, peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure. CVDs are the major cause of death in developed countries and also are rapidly emerging as a main cause of death in the developing World. The major risk factors involved in CVDs are high low density lipoprotein (LDL) cholesterol, raised blood pressure, increased serum homocysteine level and platelet aggregation, which are primarily caused by unhealthy diet, physical inactivity and tobacco use. There are various pharmaceutical formulations containing different active materials. One of them contains Telmisartan and Amlodipine besylate. Telmisartan is an angiotensin II receptor (type AT1) antagonist used in the management of hypertension. It is prevents the constriction (narrowing) of blood vessels.
Amlodipine besylate is in a class of drugs called beta-blockers. Beta-blockers affect the heart and circulatory system (arteries and veins). It is used to lower blood pressure, lower heart rate, reduce chest pain, and to reduce the risk of recurrent heart attacks. In the literature there are different studies analyzing Telmisartan, and Amlodipine besylate hence, there is no capillary electrophoresis method analyzing these drugs simultaneously. In this study a capillary electrophoretic method will be presented. The aim of study determinates the telmisartan and amlodipin besylate, simultaneously, in tablet formulation. The proposed method has been extensively validated in terms of precision, accuracy. Linear range, limit of detection and quantification values, are also calculated and discussed according to ICH Guidelines and USP criteria. The method can be used for the determination of Telmisartan and Amlodipine in their pharmaceutical preparations.

Biography :

Ebru TÜRKÖZ Acar has completed his PhD from Ondokuz May�?±s University Science Institute Analytical Chemistry Department. She is a lecturer/researcher at Yeditepe University, Faculty of Pharmacy, Analytical Chemistry department.

Email: ebruturkozacar@gmail.com