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Simultaneous Spectrophotometric Estimation Of Gemifloxacin And Ambroxol From Tablet Formulation | 7541
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Simultaneous spectrophotometric estimation of gemifloxacin and ambroxol from tablet formulation

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Khan Hajera

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

Two simple, accurate and precise UV methods were developed for the estimation of Gemifloxacin (GEM) and Ambroxol hydrochloride (AMB). from its tablet dosage form. Both the drugs are used in treatment of chronic bronchitis and mild to moderate pneumonia. The muscle spasm. Method I is Simultaneous equation method, wavelengths selected for Quantitation are 271.0 nm and 245.5 nm for c respectively which are the λmax of both the drugs. Method II is Q ?Analysis method, wavelengths selected were 271nm (λmax of GEM) and 244.0 nm (Isobestic point) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-60 μg/ml for GEM and2-12 μg/ml for AMB respectively. The results of tablet analysis for method I is found to be 99.97% + 0.041 S.D for GEM and 99.93% + 0.21 S.D for AMB and results obtained for Method II is 99.94% + 0.080 S.D for GEM and 99.90% + 0.15 S.D for AMB. The proposed methods were successfully applied for the simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated statistically.
Khan Hajera has completed her M.Pharmacy in Quality Assurance from BAMU University in 2011 .She has published 8 research papers in reputed National and international journals and presently working as assistant professor in pharmacy college.