alexa Sneddons Syndrome: Livedo Racemosa And Cerebrovascular Disease
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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10th Asia-Pacific Dermatology Conference
November 28-29, 2016 Melbourne, Australia

Sarath N Bodapati, Lauren Kunde, Gregory Butler and Daniel James
Royal Brisbane and Women’s Hospital, Australia
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.C1.048
Abstract
Introduction: Sneddon’s syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa (LRC). The cerebrovascular manifestations of SS are most often due to ischemia, including transient ischemic attacks and cerebrovascular accidents (CVA). Case: A 39-year-old women presented for routine follow-up of a net-like cyanotic discoloration over her posterior thighs and lower back. The rash had been present for 15+ years and had previously been diagnosed as idiopathic livedo reticularis (LR). On further questioning, it was revealed that the patient had a CVA at the age of 17, assumed to be secondary to amphetamine use. As such, repeat biopsies were performed and a diagnosis of LRC was confirmed; this lead to an eventual diagnosis of idiopathic SS. Discussion: The distinction between LRC and LR is relatively new concept. LR is a benign, primary disorder that affects young to middle-aged females while LRC is a secondary disorder. LRC is similar to LR in appearance but it differs in its location (more generalized and widespread), its shape (irregular, broken, circular segments) and persistence despite warmth. Conclusion: Pathophysiology of SS is not completely understood. SS likely stems from a number of acquired or congenital hemostatic abnormalities which preferentially involve cerebral and cutaneous vascular beds. Any patient suspected of SS should undergo various blood tests (e.g., thrombotic screen), skin biopsy and thorough cardiovascular evaluation (e.g., MRI head).
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