alexa Sortase A Inhibitory Activities Of Aaptamines From The Tropical Sponge Aaptos Aaptos
ISSN: 2155-9821

Journal of Bioprocessing & Biotechniques
Open Access

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15th Asia-Pacific Biotechnology Congress
July 20-22, 2017 Melbourne, Australia

Heegyu Kim, Beomkoo Chung, Eunji Cho, Ki-Bong Oh
Seoul National University, South Korea
Posters & Accepted Abstracts: J Bioprocess Biotech
DOI: 10.4172/2155-9821-C1-013
Abstract
Sortase A (SrtA) is a key enzyme that anchoring to the cell walls of Gram-positive pathogens is focused as target of antibacterial agent. It has been demonstrated that SrtA involves in the pathogenic process of bacterial infection without affecting cell viability unlikely common antibiotics. Characteristic of Gram-positive pathogens such as Staphylococcus aureus and Listeria monocytogenes revealed reduction of biofilm formation and attenuation of virulence under srtA knockout mutants, as a results, SrtA become a broad interest agent as a new target of antibiotic development models. Inhibitory activity of four aaptamines derived from extracts of the marine sponge Aaptos aaptos was determined on the basis of the fluorescent intensity fluctuation of SrtA substrates. Among them, Isoaaptamine has a strong inhibitory activity against SrtA with IC50 value of 3.7±0.2 μg/mL. Mutant S. aureus strains lacking a sortase cannot bind to cell matrix proteins, such as fibrinogen and fibronectin. The suppression of fibrinogen-binding activity by isoaaptamine indicates its potential for the treatment of S. aureus infections via inhibition of sortase activity. Consequentially, isoaaptamine is a promising candidate in the development of a bacterial SrtA inhibitor.
Biography

Heegyu Kim is student in Seoul National University, South Korea

Email: [email protected]

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