alexa Spirulina Maxima Extract Protects Against TMT-induced Neuronal Damage In HT-22 And SH-SY5Y Cells
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

JOINT EVENT: 13th International Congress on Advances in Natural Medicines Nutraceuticals & Neurocognition & 14th International Conference on Clinical Nutrition
July 27-29, 2017 Rome, Italy

Boo-Yong Lee, Eun-Jeong Koh and Young-Jin Seo
CHA University, South Korea
Posters & Accepted Abstracts: J Nutr Disorders Ther
DOI: 10.4172/2161-0509-C1-007
Abstract
Progressive neurodegeneration causes cognitive disease such as Alzheimer’s disease (AD) due to neuronal death and dysfunction of neuronal system network. Spirulina maxima is a microalga and contains protein, flavonoids, polyphenols and other essential nutrients. Recently, many studies have been demonstrated that Spirulina maxima has anti-diabetes, anticancer and anti-inflammatory effects. However, the effects of Spirulina maxima extract on cognitive disorders are not studied in detail. And so we investigate whether Spirulina maxima extract has neuroprotective effect in TMT-induced neuronal damage in neuronal cells. Trimethyltin (TMT) is a neurotoxic compound which causes neuronal cell death and is used as model of cognitive disorders. Our results showed that Spirulina maxima extract increases cell viability with TMT treatment by measuring MTT assay in HT-22 and SH-SY5Y cells. Spirulina maxima extract reduced the cleavage of poly-ADP ribose polymerase (PARP). ROS production was repressed by down regulating nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase 1 (HO-1) which is related with the oxidative stress. Recently, other publications also have been showed that Nrf2/HO-1 signaling pathways is associated with TMT-induced neuronal disorders. Furthermore, Spirulina maxima extract accelerated the neuroprotective related proteins such as brain-derived neuro-trophic factor (BDNF), and cyclic AMP responsive element binding protein (CREB) in HT-22 and SH-SY5Y cells. Conclusively in our study Spirulina maxima extract has neuroprotective effects against TMT-induced cognitive disorders in HT-22 and SH-SY5Y cells.
Biography

Boo-Yong Lee has his expertise in research and passion in improving the health and wellbeing. His open and contextual evaluation model based on responsive constructivists creates new pathways for development of functional foods and nutrigenomics. He has built this model after years of experience in Research, Evaluation, Teaching and Administration in education institutions.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords