alexa Strategies Toward Developing A Universal ExPEC Vaccine Capable Of Broad Protection
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Vaccines & Vaccination
September 24-26, 2014 Valencia Convention Centre, Spain

Melha Mellata
ScientificTracks Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.020
Abstract
E xtra-intestinal Pathogenic E. coli (ExPEC) are etiologic agents of a diverse spectrum of invasive infections in humans. They constitute an increasing problem for human medicine, especially in female, newborn, elderly, and immunocompromised patients. An increase in the appearance of antibiotic resistance among ExPEC strains complicates the therapeutic management of the infections. As the proportion of elderly and immunocompromised patients increases worldwide, the number of ExPEC infections increases and their treatment is more challenging. The difficulty of developing an effective vaccine against ExPEC is related to their diversity. A polyvalent subunit vaccine may lead to a useful strategy to prevent ExPEC infections. Multiple bacterial common antigens and/or plasmid-associated antigens of ExPEC have been evaluated individually and in combinations for their broad protection against ExPEC in animal models for sepsis and urinary tract (UTI) infections, using both active and passive immunization protocols. We have also used Recombinant attenuated Salmonella vaccine (RASV) to serve as ?factories? to synthesize protective antigens and induce high protective immune responses, and as it has adjuvant properties, induce both mucosal and systemic antibodies. Our studies evaluated both antibody titers to the antigens by measuring the IgG responses and protection using challenge studies in animal models for sepsis and UTI. They showed that vaccinated mice were less susceptible to ExPEC infections. These encouraging results highlight the importance of using certain antigen combinations in an ExPEC vaccine and warrant further investigations.
Biography
Melha Mellata has completed her PhD in Microbiology/Immunology from the University of Montreal and Postdoctoral studies from Washington University in Saint Louis and Arizona State University (ASU). She is now an Assistant Research Professor at ASU conducting research on the virulence and zoonotic risk of E. coli and collaborates with worldwide experts to design vaccines against bacterial pathogens for use in both humans and chickens. She has published papers in reputable journals
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords